CLINICAL AND MICROBIOLOGICAL ASPECTS OF CHEMOTHERAPEUTIC-AGENTS USED ACCORDING TO THE SPECIFIC PLAQUE HYPOTHESIS
CLINICAL AND MICROBIOLOGICAL ASPECTS OF CHEMOTHERAPEUTIC-AGENTS USED ACCORDING TO THE SPECIFIC PLAQUE HYPOTHESIS
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DOI：
10.1177/00220345790580120905
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发表时间：
1979-01-01
影响因子：
7.6
通讯作者：
LOESCHE, WJ
中科院分区：
文献类型：
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作者：
LOESCHE, WJ
某些形式的龋齿和牙周病似乎是由于某些本土菌斑细菌过度生长而引起的特定细菌感染，即特定菌斑假说。如果是这样，那么应该考虑基于这些微生物水平或比例升高的诊断的抗菌治疗。这种治疗不能根据非特异性斑块假说的概念进行。提出了一种治疗理念，其基础是在某些本土菌斑细菌过度生长后的医学感染中长期确立的考虑，即特定的菌斑亚微生物到感染部位的时间足够长，以抑制或摧毁病原体。给出了这种治疗理念的例子。
Certain forms of dental decay and periodontal disease appear to be due to specific bacterial infections following overgrowth of certain indigenous plaque bacteria, i.e., the specific plaque hypothesis. If so, then antimicrobial treatment based on a diagnosis of elevated levels or proportions of these organisms should be considered. Such treatment cannot be administered according to concepts of the non-specific plaque hypothesis. A treatment philosophy is presented which is based upon considerations long established in medical infections following overgrowth of certain indigenous plaque bacteria, i.e., the specific plaque hypo-microbial to the site of the infection for periods long enough to suppress or destroy the pathogenic agent. Examples of this treatment philosophy are given.