Synthetic MRI in the Detection of Multiple Sclerosis Plaques
Synthetic MRI in the Detection of Multiple Sclerosis Plaques
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DOI：
10.3174/ajnr.a5012
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发表时间：
2017-02-01
影响因子：
3.5
通讯作者：
Aoki, S.
中科院分区：
文献类型：
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作者：
Hagiwara, A.;Hori, M.;Aoki, S.
在这项回顾性研究中，合成T2加权，FLAIR，双反转恢复，和相位敏感反转恢复图像后，量化的T1和T2值和质子密度的12例MS患者。通过调整TI，对每个患者的双反转恢复图像进行优化。由放射科医师确定这4种类型的合成MR图像和一组常规T1加权反转恢复、T2加权和FLAIR图像的可见斑块数量。采用常规三维双反演恢复和其他可用图像作为标准。合成MR成像能够在相当的采集时间（约7分钟）内检测到比常规MR成像更多的MS斑块。合成双反转恢复图像上的MS斑块的对比度优于传统的双反转恢复images.Background和Purpose：合成MR成像使得能够从单个MR成像量化扫描创建各种对比加权图像，包括双反转恢复和相位敏感反转恢复。在这里，我们评估合成MR成像是否适合检测MS plaques.MATERIALS和METHODS：定量和常规MR成像数据对12例MS患者进行了回顾性分析。合成T2加权，FLAIR，双反转恢复，和相位敏感反转恢复图像后产生的T1和T2值和质子密度的量化。通过调整TI，对每个患者的双反转恢复图像进行优化。由放射科医师确定这4种类型的合成MR图像和一组常规T1加权反转恢复、T2加权和FLAIR图像的可见斑块数量。采用常规三维双反演恢复和其他可用图像作为标准。合成MR成像的总采集时间为7分12秒，常规MR成像的总采集时间为6分29秒。计算合成和常规双反转恢复图像之间的病灶与WM对比度和病灶与WM对比噪声比。合成和常规MR图像检测到的斑块总数分别为157和139（P = 0.014）。合成双反转恢复图像上的病变与WM对比度和对比噪声比上级常规双反转恢复图像上的病变与WM对比度和对比噪声比（分别为P = 0.001和< 0.001）。结论：合成MR成像能够在可比的采集时间内检测到比常规MR成像更多的MS斑块。合成双反转恢复图像上MS斑块的对比度优于常规双反转恢复图像。
In this retrospective study, synthetic T2-weighted, FLAIR, double inversion recovery, and phase-sensitive inversion recovery images were produced in 12 patients with MS after quantification of T1 and T2 values and proton density. Double inversion recovery images were optimized for each patient by adjusting the TI. The number of visible plaques was determined by a radiologist for a set of these 4 types of synthetic MR images and a set of conventional T1-weighted inversion recovery, T2-weighted, and FLAIR images. Conventional 3D double inversion recovery and other available images were used as the criterion standard. Synthetic MR imaging enabled detection of more MS plaques than conventional MR imaging in a comparable acquisition time (approximately 7 minutes). The contrast for MS plaques on synthetic double inversion recovery images was better than on conventional double inversion recovery images.BACKGROUND AND PURPOSE: Synthetic MR imaging enables the creation of various contrast-weighted images including double inversion recovery and phase-sensitive inversion recovery from a single MR imaging quantification scan. Here, we assessed whether synthetic MR imaging is suitable for detecting MS plaques.MATERIALS AND METHODS: Quantitative and conventional MR imaging data on 12 patients with MS were retrospectively analyzed. Synthetic T2-weighted, FLAIR, double inversion recovery, and phase-sensitive inversion recovery images were produced after quantification of T1 and T2 values and proton density. Double inversion recovery images were optimized for each patient by adjusting the TI. The number of visible plaques was determined by a radiologist for a set of these 4 types of synthetic MR images and a set of conventional T1-weighted inversion recovery, T2-weighted, and FLAIR images. Conventional 3D double inversion recovery and other available images were used as the criterion standard. The total acquisition time of synthetic MR imaging was 7 minutes 12 seconds and that of conventional MR imaging was 6 minutes 29 seconds The lesion-to-WM contrast and lesion-to-WM contrast-to-noise ratio were calculated and compared between synthetic and conventional double inversion recovery images.RESULTS: The total plaques detected by synthetic and conventional MR images were 157 and 139, respectively (P = .014). The lesion-to-WM contrast and contrast-to-noise ratio on synthetic double inversion recovery images were superior to those on conventional double inversion recovery images (P = .001 and < 0.001, respectively).CONCLUSIONS: Synthetic MR imaging enabled detection of more MS plaques than conventional MR imaging in a comparable acquisition time. The contrast for MS plaques on synthetic double inversion recovery images was better than on conventional double inversion recovery images.