Effects of Tai Chi on glucose homeostasis and insulin sensitivity in older adults with type 2 diabetes: a randomised double-blind sham-exercise-controlled trial
Effects of Tai Chi on glucose homeostasis and insulin sensitivity in older adults with type 2 diabetes: a randomised double-blind sham-exercise-controlled trial
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DOI：
10.1093/ageing/afm127
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发表时间：
2008-01-01
期刊：
影响因子：
6.7
通讯作者：
Singh, Maria Fiatarone
中科院分区：
文献类型：
--
作者：
Tsang, Tracey;Orr, Rhonda;Singh, Maria Fiatarone
背景：尽管有证据表明运动对2型糖尿病有益，但仍有很大比例的2型糖尿病成年人保持久坐不动。一项研究表明，简化的杨太极拳对老年人的胰岛素敏感性没有影响。然而，修改后的太极形式，太极糖尿病（中药）最近组成，声称可以改善diabetescontrol.Methods：受试者被随机分配到太极或假锻炼，每周两次，持续16周。主要结果为运动后72小时胰岛素抵抗（HOMA2-IR）和长期血糖控制（HbA（1c））。基线BMI为32.2 +/-6.3 kg/m2，84%患有骨关节炎，76%患有高血压，34%患有心脏病。有1例脱落，无不良事件，中位依从性为100（0 - 100）%。第16周时，时间或分组对胰岛素抵抗或HbA（1c）无影响（太极拳组为-0.07 +/-0.4%，假组为0.12 +/-0.3%; P = 0.13）。HbA1c的改善与体脂减少相关（r = 0.484，P = 0.004），胰岛素抵抗的改善与体脂的减少有关（r = 0.37，P = 0.03）和中心性肥胖（r = 0.38，P = 0.02），以及无脂质量增加结论：运动后72 h，TCD对血糖稳态和胰岛素敏感性无明显改善作用。可能需要更激烈的太极形式来产生与2型糖尿病代谢益处相关的身体成分变化。
Background: a large proportion of adults with type 2 diabetes remain sedentary despite evidence of benefits from exercise for type 2 diabetes. Simplified Yang Tai Chi has been shown in one study to have no effect on insulin sensitivity in older adults. However, a modified Tai Chi form, Tai Chi for Diabetes (TCD) has recently been composed, claiming to improve diabetes control.Methods: subjects were randomised to Tai Chi or sham exercise, twice a week for 16 weeks. Primary outcomes were insulin resistance 72 h post-exercise (HOMA2-IR), and long-term glucose control (HbA(1c)).Results thirty-eight subjects (65 +/- 7.8 years, 79% women) were enrolled. Baseline BMI was 32.2 +/- 6.3 kg/ m(2), 84% had osteoarthritis, 76% hypertension, and 34% cardiac disease. There was one dropout, no adverse events, and median compliance was 100 (0 - 100)%. There were no effects of time or group assignment on insulin resistance or HbA(1c) (- 0.07 +/- 0.4% Tai Chi versus 0.12 +/- 0.3% Sham; P = 0.13) at 16 weeks. Improvement in HbA1c was related to decreased body fat (r = 0.484, P = 0.004) and improvement in insulin resistance was related to decreased body fat (r = 0.37, P = 0.03) and central adiposity (r = 0.38, P = 0.02), as well as increased fat-free mass (r = -0.46, P = 0.005).Conclusions: TCD did not improve glucose homeostasis or insulin sensitivity measured 72 h after the last bout of exercise. More intense forms of Tai Chi may be required to produce the body composition changes associated with metabolic benefits in type 2 diabetes.