Relationship between semen production and medical comorbidity
Relationship between semen production and medical comorbidity
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DOI：
10.1016/j.fertnstert.2014.10.017
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发表时间：
2015-01-01
影响因子：
6.7
通讯作者：
Cullen, Mark R.
中科院分区：
文献类型：
--
作者：
Eisenberg, Michael L.;Li, Shufeng;Cullen, Mark R.
目的：研究一组男性不育症患者精液质量与当前健康状况的关系。设计：横断面研究。设置：生育诊所。患者：1994年至2011年间9387名男性不育症患者。干预：无。主要结局指标：Charlson合并症指数，器官系统医学诊断。结果：在评估时，9，387名平均年龄为38岁的男性有精液数据。在这些男性中，44%的人至少有一次与不孕症无关的医学诊断。当通过Charlson共病指数（CCI）对队列进行分层时，确定了所有测量的精液参数的差异。CCI较高的男性精液量、浓度、活力、精子总数和形态评分较低。此外，患有内分泌、循环系统、泌尿生殖系统和皮肤疾病的男性精液异常率都显着较高。经过仔细检查的循环系统疾病，男性高血压病，外周血管和脑血管疾病，和nonischemic心脏病都表现出较高的精液abnormality.Conclusions（S）：目前的报告确定了医疗合并症和男性精液生产之间的关系。虽然遗传学有助于指导男性的精子生产，但他目前的状况和健康状况起着重要作用。(C)2015年，美国生殖医学会（American Society for Reproductive Medicine）
Objective: To study the relationship between semen quality and current health status in a cohort of men evaluated for infertility.Design: Cross-sectional study.Setting: Fertility clinic.Patient(s): Nine thousand three hundred eighty-seven men evaluated for infertility between 1994 and 2011.Intervention(s): None.Main Outcome Measure(s): Charlson comorbidity index, medical diagnoses by organ system.Result(s): At the time of evaluation, 9,387 men with a mean age of 38 years had semen data available. Of these men, 44% had at least one medical diagnosis unrelated to infertility. When stratifying the cohort by the Charlson comorbidity index (CCI), differences in all measured semen parameters were identified. Men with a higher CCI had lower semen volume, concentration, motility, total sperm count, and morphology scores. In addition, men with diseases of the endocrine, circulatory, genitourinary, and skin diseases all showed significantly higher rates of semen abnormalities. Upon closer examination of diseases of the circulatory system, men with hypertensive disease, peripheral vascular and cerebrovascular disease, and nonischemic heart disease all displayed higher rates of semen abnormalities.Conclusion(s): The current report identified a relationship between medical comorbidites and male semen production. Although genetics help guide a man's sperm production, his current condition and health play an important role. (C) 2015 by American Society for Reproductive Medicine.