OXYGEN DELIVERY FROM RED-CELLS
OXYGEN DELIVERY FROM RED-CELLS
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DOI：
10.1016/s0006-3495(85)83890-x
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发表时间：
1985-01-01
影响因子：
3.4
通讯作者：
COKELET, GR
中科院分区：
文献类型：
--
作者：
CLARK, A;FEDERSPIEL, WJ;COKELET, GR
本文对红细胞中氧的卸载进行了理论分析。控制输运方程的尺度分析表明，溶液在红细胞膜附近具有边界层结构。边界层是化学非平衡区，它的存在是由于红细胞的动力学时标短于扩散时标。边界层的存在允许用匹配渐近展开的方法得到解析解。从分析中得到的一个非常有用的结果是一个简单的、集总参数的红细胞氧输送描述。通过将集总参数描述的预测结果与一维平板全方程的数值积分结果进行比较，验证了集总参数描述的准确性。作为一种应用，计算了红细胞的最小O2卸载时间。
This paper deals with the theoretical analysis of unloading of O2 from a red cell. A scale analysis of the governing transport equations shows that the solutions have a boundary layer structure near the red-cell membrane. The boundary layer is a region of chemical nonequilibrium, and it owes its existence to the fact that the kinetic time scales are shorter than the diffusion time scales in the red cell. The presence of the boundary layer allows an analytical solution to be obtained by the method of matched asymptotic expansions. A very useful result from the analysis is a simple, lumped-parameter description of the O2 delivery from a red cell. The accuracy of the lumped-parameter description was verified by comparing its predictions with results obtained by numerical integration of the full equations for a 1-dimensional slab. As an application, minimum O2 unloading times for red cells are calculated.