The correlation between the tumor necrosis and renal artery changes in renal cell carcinoma
The correlation between the tumor necrosis and renal artery changes in renal cell carcinoma
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DOI：
10.1177/1066896906293348
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发表时间：
2006-10-01
影响因子：
1.2
通讯作者：
Belicza, Mladen
中科院分区：
文献类型：
--
作者：
Kruslin, Bozo;Tomic, Karla;Belicza, Mladen
坏死、囊肿、出血和钙化是肾细胞癌的常见表现。不同的病变，包括动脉硬化或纤维肌性发育不良，或两者，可能涉及主要肾动脉。本研究分析了112例肾细胞癌患者（71例男性，41例女性）的肾动脉变化与肾细胞癌坏死的存在和程度之间的关系，平均肾细胞癌为7.7 cm（范围，2至20 cm）。88例（78.6%）肉眼可见坏死，其中64例肿瘤坏死小于50%，24例肿瘤坏死大于50%。41例患者（36.6%; 17名男性，24名女性）发现纤维肌发育不良，21例患者（18.8%; 18名男性，3名女性）发现动脉粥样硬化改变。结果表明，肾细胞癌坏死在伴有纤维肌性发育不良（尤其是1型）的女性和伴有肾动脉粥样硬化病变的男性中明显更常见。
Necrosis, cysts, hemorrhage, and calcification represent common findings in renal cell carcinoma. Different lesions, including arteriosclerosis or fibromuscular dysplasia, or both, may involve the main renal artery. This study analyzed the relationship between the presence and extent of necrosis in renal cell carcinoma with renal artery changes in a consecutive series of 112 patients (71 men, 41 women) with mean renal cell carcinoma of 7.7 cm (range, 2 to 20 cm). Necrosis was seen macroscopically and confirmed microscopically in 88 cases (78.6%), with 64 tumors having less than 50% and 24 more than 50% necrosis. Fibromuscular dysplasia was found in 41 patients (36.6%; 17 men, 24 women) and atherosclerotic changes in 21 patients (18.8%; 18 men, 3 women). The results suggest that necrosis of renal cell carcinoma was significantly more common in women with associated fibromuscular dysplasia (especially type 1) and men with atherosclerotic changes of renal artery.