Parental mood during pregnancy and post-natally is associated with offspring risk of Tourette syndrome or chronic tics: prospective data from the Avon Longitudinal Study of Parents and Children (ALSPAC).
Parental mood during pregnancy and post-natally is associated with offspring risk of Tourette syndrome or chronic tics: prospective data from the Avon Longitudinal Study of Parents and Children (ALSPAC).
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DOI：
10.1007/s00787-015-0742-0
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发表时间：
2016-04
影响因子：
6.4
通讯作者：
Mathews CA
中科院分区：
文献类型：
--
作者：
Ben-Shlomo Y;Scharf JM;Miller LL;Mathews CA
关于Tourette综合征（TS）和慢性抽动障碍（CT）的危险因素知之甚少，但妊娠期母体心理疾病可能与TS/CT相关。我们在雅芳父母和儿童纵向研究中研究了产前和产后父母的焦虑和/或抑郁是否与TS/CT的风险相关。我们比较了在4个时间点（产前18周和32周，产后8周和8个月）前瞻性收集的自我报告的焦虑和抑郁测量值，这些时间点是13岁时符合TS/CT标准的儿童的父母与队列中的其他儿童。我们调整了各种社会经济指标，并使用多变量logistic回归模型测试了特定时间段的暴露和慢性暴露。122名儿童有TS/CT（50名TS，72名CT），5968名儿童无抽搐。在粗略的分析中，产前和产后母亲的焦虑和抑郁，但只有产后8个月的父亲抑郁，显示与TS/CT。在最后一个调整后的多变量模型中，（比值比2.17，95% CI 1.23，3.84，p = 0.007）和产前母亲抑郁症（比值比1.86，95%CI 1.02，3.39，p = 0.04）显示与TS/CT相关，尽管后者在调整过去的母亲抑郁后与机会一致（p = 0.07）。我们发现产妇的心理发病率产前和产后和未来TS/CT的风险在后代之间的关联。这些关联可能反映了共同的遗传易感性或产前暴露。需要进一步的工作，看看这些发现是否可以在更大的数据集中复制。本文的在线版本（doi：10.1007/s 00787 -015-0742-0）包含补充材料，可供授权用户使用。
Little is known about risk factors for Tourette syndrome (TS) and chronic tic disorders (CT) but maternal psychological morbidity in pregnancy may be associated with TS/CT. We examined whether pre- and post-natal parental anxiety and/or depression are associated with risk of TS/CT in the Avon Longitudinal Study of Parents and Children. We compared self-reported anxiety and depression measures collected prospectively at four time points (18 and 32 weeks prenatally, and 8 weeks and 8 months post-natally) among parents of children who subsequently met criteria for TS/CT at 13 years of age as compared to other children from the cohort. We adjusted for various socioeconomic measures and tested both for time period-specific exposure and chronic exposure using multivariable logistic regression models. 122 children had TS/CT (50 TS, 72 CT) and 5968 children had no tics. In crude analyses, both pre- and post-natal maternal anxiety and depression, but only post-natal paternal depression at 8 months, showed associations with TS/CT. In the final, adjusted multivariable models, chronic maternal anxiety (odds ratio 2.17, 95 % CI 1.23, 3.84, p = 0.007) and pre-natal maternal depression (odds ratio 1.86, 95 % CI 1.02, 3.39, p = 0.04) showed associations with TS/CT though the latter was consistent with chance (p = 0.07) after adjustment for past maternal depression. We find associations between maternal psychological morbidity pre- and post-natally and risk of future TS/CT in offspring. These associations may reflect either shared genetic susceptibility or a pre-natal exposure. Further work is required to see if these findings can be replicated in larger datasets. The online version of this article (doi:10.1007/s00787-015-0742-0) contains supplementary material, which is available to authorized users.