Therapeutic vaccination of rabbits with a ubiquitin-fused papillomavirus E1, E2, E6 and E7 DNA vaccine
Therapeutic vaccination of rabbits with a ubiquitin-fused papillomavirus E1, E2, E6 and E7 DNA vaccine
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DOI：
10.1016/j.vaccine.2007.06.012
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发表时间：
2007-08-14
期刊：
影响因子：
5.5
通讯作者：
Su, Yuhua
中科院分区：
文献类型：
--
作者：
Brandsma, Janet L.;Shlyankevich, Mark;Su, Yuhua
Previously, we showed that intracutaneous vaccination of rabbits with DNA vectors encoding ubiquitin-fused versions of the cottontail rabbit papillomavirus (CRPV) early proteins El, E2, E6 and E7 protected against subsequent challenge with CRPV. Here, we tested the immunotherapentic activity of a vaccine composed of the four CRPV DNA vectors (designated UbE1267) in rabbits. The results show that the UbE1267 DNA vaccine, relative to empty vector DNA, virtually eliminated papilloma growth in rabbits with subclinical infection and greatly reduced papilloma volumes in rabbits bearing papillomas at the time of vaccination. These results in a physiologically relevant animal model of high-risk human papillomavirus (HPV) infection indicate that DNA vaccines targeting the early papillomavirus proteins may have a role in the treatment of HPV-associated lesions in humans. (c) 2007 Elsevier Ltd. All rights reserved.
