The pheromone darcin drives a circuit for innate and reinforced behaviours
The pheromone darcin drives a circuit for innate and reinforced behaviours
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DOI：
10.1038/s41586-020-1967-8
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发表时间：
2020-01-29
期刊：
影响因子：
64.8
通讯作者：
Axel, Richard
中科院分区：
文献类型：
--
作者：
Demir, Ebru;Li, Kenneth;Axel, Richard
生物体已经进化出不同的行为策略，提高了遇到和评估配偶的可能性（1）。许多物种使用信息素来传达有关潜在伴侣的位置，性和社会地位的信息（2）。在小鼠中，主要的尿蛋白darcin-存在于男性的尿液中-提供了一种气味标记的成分，可以刺激女性的接近并驱动学习（3，4）。在这里，我们表明，darcin elevolent一个复杂而多变的行为剧目，包括吸引力，超声波发声和尿气味标记，也作为一个学习范式的administrator。我们确定了一个由基因决定的回路从副嗅球延伸到杏仁后内侧，这是所有对darcin的行为反应所必需的。此外，光学激活内侧杏仁核的darcin-responsive神经元诱导的先天性和条件性行为引起的信息素。这些神经元定义了一个拓扑隔离的人口，表达神经元型一氧化氮合酶。我们认为，这种由darcin激活的神经回路整合了信息素信息和内部状态，从而引发了可能促进配偶相遇和配偶选择的可变的先天行为和强化行为;由雄性信息素darcin激活的神经回路介导了可能促进配偶相遇和配偶选择的一系列复杂而可变的先天行为和强化行为。
Organisms have evolved diverse behavioural strategies that enhance the likelihood of encountering and assessing mates(1). Many species use pheromones to communicate information about the location, sexual and social status of potential partners(2). In mice, the major urinary protein darcin-which is present in the urine of males-provides a component of a scent mark that elicits approach by females and drives learning(3,4). Here we show that darcin elicits a complex and variable behavioural repertoire that consists of attraction, ultrasonic vocalization and urinary scent marking, and also serves as a reinforcer in learning paradigms. We identify a genetically determined circuit-extending from the accessory olfactory bulb to the posterior medial amygdala-that is necessary for all behavioural responses to darcin. Moreover, optical activation of darcin-responsive neurons in the medial amygdala induces both the innate and the conditioned behaviours elicited by the pheromone. These neurons define a topographically segregated population that expresses neuronal nitric oxide synthase. We suggest that this darcin-activated neural circuit integrates pheromonal information with internal state to elicit both variable innate behaviours and reinforced behaviours that may promote mate encounters and mate selection.A neural circuit activated by the male pheromone, darcin, mediates a complex and variable array of innate and reinforced behaviours that may promote mate encounters and mate selection.