A novel 3,6-diamino-1,8-naphthalimide derivative as a highly selective fluorescent "turn-on" probe for thiols
A novel 3,6-diamino-1,8-naphthalimide derivative as a highly selective fluorescent "turn-on" probe for thiols
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一种新型 3,6-二氨基-1,8-萘二甲酰亚胺衍生物，作为硫醇的高选择性荧光“开启”探针
DOI：
10.1039/c5ra03849a
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发表时间：
2015-01-01
期刊：
影响因子：
3.9
通讯作者：
Chen, Wen-Hua
中科院分区：
文献类型：
--
作者：
Dong, Cheng;Zhou, Chun-Qiong;Chen, Wen-Hua
合成了一种新的含3-氨基和6-（2，4-二硝基苯磺酰胺基）的1，8-萘酰亚胺衍生物，并发现其对半胱氨酸、同型半胱氨酸和谷胱甘肽等生物硫醇具有荧光“开启”响应。该化合物表现出高选择性和低检测限，特别是对Cys。传感机制涉及的2，4-二硝基苯磺酰胺基的断裂和形成的给电子氨基。此外，还简要讨论了它的细胞成像特性。
A novel 1,8-naphthalimide derivative bearing 3-amino and 6-(2,4-dinitrobenzenesulfonamido) groups was synthesized and found to exhibit a fluorescent "turn-on" response to biothiols, including Cys, Hcy and GSH. This compound exhibited high selectivity and low detection limit, in particular toward Cys. The sensing mechanism involved the cleavage of the 2,4-dinitrobenzenesulfonamido group and the formation of an electron-donating amino group. In addition, its properties for cellular imaging were also briefly discussed.