Capsaicin-Induced β-Adrenergic Action on Energy Metabolism in Rats: Influence of Capsaicin on Oxygen Consumption, the Respiratory Quotient, and Substrate Utilization 1
Capsaicin-Induced β-Adrenergic Action on Energy Metabolism in Rats: Influence of Capsaicin on Oxygen Consumption, the Respiratory Quotient, and Substrate Utilization 1
复制标题
DOI：
10.3181/00379727-183-42414
复制
发表时间：
1986-11
影响因子：
--
通讯作者：
T. Kawada;Tatsuo Watanabe;Tomoko Takaishi;Takehiko Tanaka;K. Iwai
中科院分区：
文献类型：
--
作者：
T. Kawada;Tatsuo Watanabe;Tomoko Takaishi;Takehiko Tanaka;K. Iwai
摘要研究了辣椒素对大鼠能量代谢的作用方式。腹腔注射辣椒素（6.0mg/kg）时的耗氧量高于不注射时的耗氧量。呼吸商（R.Q.）在施用辣椒素后增加然后降低。血清葡萄糖和免疫反应性胰岛素水平迅速上升后，辣椒素的管理。此外，肝糖原迅速减少，与血清葡萄糖浓度迅速增加相反。血清游离脂肪酸水平逐渐增加后，辣椒素的管理。辣椒素给药后能量代谢的这些变化与肾上腺素代谢的变化相似，并且被各种β-肾上腺素能阻滞剂特异性抑制。另一方面，α-肾上腺素能受体阻滞剂或神经节阻滞剂预处理不影响这些变化。这些结果表明，辣椒素增强大鼠能量代谢的作用模式包括直接（作为激动剂）和/或间接（通过儿茶酚胺）β-肾上腺素能作用。因此，推测辣椒素的肾上腺素能作用至少部分地导致喂食补充有辣椒素的高脂肪饮食的大鼠的肾周脂肪组织重量和血清甘油三酯浓度的降低（T. Kawada等人，J Nutr 116：1272-1278，1986）。
Abstract The mode of action of capsaicin on energy metabolism was investigated in rats. The oxygen consumption was higher when capsaicin (6.0 mg/kg) was intraperitoneally injected than when it was not injected. The respiratory quotient (R.Q.) increased and then decreased after the administration of capsaicin. The levels of serum glucose and immunoreactive insulin rapidly increased after the administration of capsaicin. Also, liver glycogen rapidly decreased, in contrast to the serum glucose concentration which rapidly increased. The serum-free fatty acid level gradually increased after the administration of capsaicin. These alterations in energy metabolism on the administration of capsaicin were similar to those in the metabolism of epinephrine, and were specifically inhibited by various β-adrenergic blockers. On the other hand, the alterations were not affected by pretreatment with α-adrenergic or ganglion blockers. These results suggest that the mode of action of capsaicin on the enhancement of energy metabolism in rats comprises a direct (as an agonist) and/or an indirect (via catecholamine) β-adrenergic action. Therefore, it was speculated that the adrenergic action of capsaicin resulted, at least in part, in a decrease in the perirenal adipose tissue weight and serum triglyceride concentration in rats fed a high fat diet supplemented with capsaicin (T. Kawada et al., J Nutr 116:1272–1278, 1986).