A DROSOPHILA GENE THAT IS HOMOLOGOUS TO A MAMMALIAN GENE ASSOCIATED WITH TUMOR-METASTASIS CODES FOR A NUCLEOSIDE DIPHOSPHATE KINASE
A DROSOPHILA GENE THAT IS HOMOLOGOUS TO A MAMMALIAN GENE ASSOCIATED WITH TUMOR-METASTASIS CODES FOR A NUCLEOSIDE DIPHOSPHATE KINASE
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DOI：
10.1016/0092-8674(90)90496-2
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发表时间：
1990-11-30
期刊：
影响因子：
64.5
通讯作者：
SHEARN, A
中科院分区：
文献类型：
--
作者：
BIGGS, J;HERSPERGER, E;SHEARN, A
果蝇异常翼盘(awd)基因的产物与哺乳动物nm23基因的产物有78%的同一性，在某些转移性肿瘤中差异表达。我们提供的证据表明 awd 基因编码核苷二磷酸激酶（NDP 激酶），并且该 Awd/NDP 激酶与微管相关。 awd 基因无效突变的果蝇幼虫中的神经母细胞在中期停滞，表明微管相关的 Awd/NDP 激酶在纺锤体微管聚合中起着关键作用。
The product of the abnormal wing discs (awd) gene of Drosophila is 78% identical to the product of the nm23 gene of mammals, which is differentially expressed in certain metastatic tumors. We present evidence that the awd gene codes for a nucleoside diphosphate kinase (NDP kinase) and that this Awd/NDP kinase is microtubule associated. Neuroblasts in Drosophila larvae homozygous for a null mutation in the awd gene are arrested in metaphase, indicating that microtubule-associated Awd/NDP kinase plays a critical role in spindle microtubule polymerization.