Passive transfer of arthritis to mice by injection of human anti-type II collagen antibody.
Passive transfer of arthritis to mice by injection of human anti-type II collagen antibody.
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DOI：
10.1016/s0025-6196(12)65583-9
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发表时间：
1984-11
影响因子：
8.9
通讯作者：
P. Wooley;H. Luthra;S. Singh;A. Huse;J. Stuart;C. David
中科院分区：
文献类型：
--
作者：
P. Wooley;H. Luthra;S. Singh;A. Huse;J. Stuart;C. David
将来自血清阴性类风湿样关节炎患者的血清IgG组分静脉内注射到对II型胶原诱导的关节炎敏感的小鼠中，所述血清IgG组分含有高抗II型胶原抗体滴度。在20%至25%的动物中观察到轻度、短暂的炎性关节炎，而在大多数注射小鼠中，疾病的组织学体征明显。将纯化的人抗II型胶原免疫球蛋白注射到小鼠膝关节中也显示出诱导短暂的炎性关节炎。放射性标记的人抗II型胶原IgG显示在小鼠的外周关节中积累，并且抗体的特异性显示与从患有胶原诱导的关节炎的小鼠的关节洗脱的抗胶原抗体的特异性相似。
The serum IgG fraction from a patient with seronegative rheumatoid-like arthritis which contained a high anti-type II collagen antibody titer was injected intravenously into mice susceptible to type II collagen-induced arthritis. A mild, transient, inflammatory arthritis was observed in 20 to 25% of the animals, whereas histologic signs of disease were evident in most of the injected mice. Purified human anti-type II collagen immunoglobulin injected into the knee joints of mice was also shown to induce a transient, inflammatory arthritis. Radiolabeled human anti-type II collagen IgG was shown to accumulate in the peripheral joints of mice, and the specificity of the antibody was shown to be similar to the specificity of anticollagen antibody eluted from the joints of mice with collagen-induced arthritis.