Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.
Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.
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DOI：
10.1007/s13659-018-0156-z
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发表时间：
2018-04
影响因子：
4.7
通讯作者：
Zhang YJ
中科院分区：
文献类型：
--
作者：
Zhang H;Zhu HT;Wang D;Yang CR;Zhang YJ
从青曲霉 (Aspergillus penicilliodes Speg.) 的菌丝体培养物中分离得到 12 种吲哚基二酮哌嗪 1-12，青曲霉是成熟普洱茶后发酵过程中的优势微生物。通过广泛的光谱方法阐明了它们的结构。其中，C-2位具有罕见的甲基乙烯基酮侧链的胰蛋白酶抑制剂C(1)和D(2)是新化合物，而3和4是首次从天然来源获得。分离株 3-12 在 40 μM 浓度下对五种人类癌细胞系没有表现出明显的细胞毒性。本文的在线版本 (10.1007/s13659-018-0156-z) 包含补充材料，可供授权用户使用。
Twelve indolyl diketopiperazines 1–12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3–12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM. The online version of this article (10.1007/s13659-018-0156-z) contains supplementary material, which is available to authorized users.