Biomarkers for kidney involvement in pediatric lupus.
Biomarkers for kidney involvement in pediatric lupus.
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DOI：
10.2217/bmm.15.25
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发表时间：
2015
影响因子：
2.2
通讯作者：
Rubinstein TB
中科院分区：
文献类型：
--
作者：
Goilav B;Putterman C;Rubinstein TB
狼疮性肾炎（LN）是系统性红斑狼疮的肾脏受累，目前通过经皮肾活检获得的组织病理学诊断，并且与成人和儿童的发病率和死亡率增加相关。LN在儿童中更为普遍和严重，需要积极和长期的免疫抑制。诊断及其治疗的后果对受影响儿童的生长、福祉和生活质量产生毁灭性的长期影响。近年来，由于缺乏可靠的临床指标来判断肾脏受累的存在和严重程度，导致终末期肾病进展的减少。在这里，我们讨论了最近的发展，生物标志物在LN的管理和他们的作用作为治疗目标。
Lupus nephritis (LN), the renal involvement in systemic lupus erythematosus, is currently diagnosed by histopathology obtained by percutaneous renal biopsy and is associated with increased morbidity and mortality in both adults and children. LN is more prevalent and severe in children, requiring aggressive and prolonged immunosuppression. The consequences of the diagnosis and its treatment have devastating long-term effects on the growth, well-being and quality of life of affected children. The paucity of reliable clinical indicators of the presence and severity of renal involvement have contributed to a halt in the reduction of progression to end-stage renal disease in recent years. Here, we discuss the recent development of biomarkers in the management of LN and their role as therapeutic targets.