Social and novel contexts modify hippocampal CA2 representations of space.
Social and novel contexts modify hippocampal CA2 representations of space.
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社会和新颖的环境修改了海马CA2空间的表示。
DOI：
10.1038/ncomms10300
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发表时间：
2016-01-25
影响因子：
16.6
通讯作者：
Dudek SM
中科院分区：
文献类型：
--
作者：
Alexander GM;Farris S;Pirone JR;Zheng C;Colgin LL;Dudek SM
海马体支持认知空间地图，对编码陈述性记忆（谁、什么、何时、何地）至关重要。最近的研究暗示海马体子区CA2在社会和情境记忆中，但它是如何做到的仍然未知。在这里，我们发现在成年雄性大鼠中，社会刺激（新的或熟悉的大鼠）或新物体的呈现诱导CA2中位置场的全局重新定位，而对神经元放电率或立即早期基因表达没有影响。这种重新定位没有发生在CA1中，这表明这种效应是CA2特有的。因此，对现有空间表征的修改可能是CA2编码社会和新上下文信息的潜在机制。最近的研究表明海马子区CA2参与了社会记忆和情境记忆的编码，但神经机制尚不清楚。在这里，Alexander和他的同事们证明，与CA1神经元相比，CA2神经元在面对社会或新的刺激时改变了它们的位置场。
The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how it does so remains unknown. Here we find that in adult male rats, presentation of a social stimulus (novel or familiar rat) or a novel object induces global remapping of place fields in CA2 with no effect on neuronal firing rate or immediate early gene expression. This remapping did not occur in CA1, suggesting this effect is specific for CA2. Thus, modification of existing spatial representations might be a potential mechanism by which CA2 encodes social and novel contextual information. Recent work has implicated hippocampal subfield CA2 in encoding social and contextual memory yet the neural mechanisms are not known. Here, Alexander and colleagues demonstrate that, compared to CA1 neurons, CA2 neurons modify their place fields when presented with social or novel stimuli.