Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.
Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.
复制标题
老年猫的成纤维细胞生长因子 23 和对称二甲基精氨酸浓度。
DOI：
10.1111/jvim.15590
复制
发表时间：
2019
影响因子：
2.6
通讯作者：
Sargent HJ
中科院分区：
文献类型：
--
作者：
Sargent HJ
成纤维细胞生长因子23 （FGF23）是一种磷酸化激素，在患有慢性肾脏疾病（CKD）的azotemia猫中升高，并预测老年猫azotemia的发病。引入对称二甲基精氨酸（SDMA）作为肾小球滤过率的生物标志物，可以鉴定出SDMA升高的猫，但血浆肌酐浓度仍在参考范围内。目前对这种猫的代谢变化了解甚少。目的探讨非氮化老年猫血浆FGF23与SDMA浓度的关系。没有azotic CKD的客户猫的横截面记录（n = 143）。方法从2次第一意见实践记录中获取猫（≥9岁）的临床病理信息。血浆SDMA和FGF23浓度之间的关系采用Spearman相关检验，变量采用Mann - whitneytest比较。结果与SDMA浓度在参考范围内的猫相比，SDMA浓度升高的猫血浆FGF23 （P< 0.001）和肌酐（P< 0.001）浓度显著升高。血浆FGF23与SDMA浓度呈弱正相关（r= 0.35，P< 0.001），血浆FGF23与肌酐浓度呈弱正相关（r= 0.23，P= 0.005）。结论和临床意义SDMA浓度升高的猫比SDMA浓度在参考范围内的猫有更多的FGF23浓度，这表明磷酸盐稳态存在改变。需要进一步的研究来确定影响因素，并探索FGF23浓度在早期CKD猫的管理中的作用。
BackgroundFibroblast growth factor 23 (FGF23) is a phosphaturic hormone that is increased in azotemic cats with chronic kidney disease (CKD) and predictive of the onset of azotemia in older cats. The introduction of symmetric dimethylarginine (SDMA) as a biomarker of glomerular filtration rate has led to the identification of cats in which SDMA is increased, but plasma creatinine concentrations remains within reference range. There is currently little understanding of the metabolic changes present in such cats.ObjectivesTo examine the relationship between plasma FGF23 and SDMA concentrations in non‐azotemic geriatric cats.AnimalsRecords of a cross section of client‐owned cats (n = 143) without azotemic CKD.MethodsClinicopathological information was obtained from cats (≥ 9 years) from records of 2 first opinion practices. The relationship between plasma SDMA and FGF23 concentrations was examined using Spearman's correlation and variables compared using the Mann‐WhitneyUtest.ResultsCats with increased SDMA concentrations had significantly higher plasma FGF23 (P< .001) and creatinine (P< .001) concentrations compared to cats with SDMA concentrations within reference range. A weak positive relationship was demonstrated between plasma FGF23 and SDMA concentrations (r= .35,P< .001) and between plasma FGF23 and creatinine (r= .23,P= .005) concentrations.Conclusions and Clinical ImportanceMore cats with increased SDMA concentrations had higher FGF23 concentrations than those with SDMA concentrations within the reference range, suggesting the presence of an alteration in phosphate homeostasis. Further studies are warranted to identify influencing factors and to explore the utility of FGF23 concentration to inform management of cats with early stage CKD.