Creation of a tailored aldolase for the parallel synthesis of sialic acid mimetics.
Creation of a tailored aldolase for the parallel synthesis of sialic acid mimetics.
复制标题
创建用于平行合成唾液酸模拟物的定制醛缩酶。
作者：
T. Woodhall;Gavin J. Williams;A. Berry;A. Nelson
事实上，高水平的底物专一性、立体选择性和化学选择性是酶催化的特点。然而，对合成化学家来说，最有用的催化剂是那些广泛适用的催化剂。事实上，夏普莱斯已经从其非凡的范围评论了非对称双羟基化的合成优点：
Indeed, high levels ofsubstrate specificity, and stereo- and chemoselectivity arehallmarks of enzymatic catalysis.The most useful catalysts to the synthetic chemist,however, are those that are broadly applicable. Indeed,Sharpless has commented on the synthetic virtues of asym-metric dihydroxylation in terms of its remarkable scope: “It[OsO
影响因子：
5.2
作者：
Chappell,MD;Halcomb,RL
通讯作者：
Halcomb,RL