Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese
Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese
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DOI：
10.1002/ijc.24519
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发表时间：
2009-10-15
影响因子：
6.4
通讯作者：
Tanaka, Hideo
中科院分区：
文献类型：
--
作者：
Matsuo, Keitaro;Tajima, Kazuo;Tanaka, Hideo
最近的一项全基因组关联研究确定了前列腺干细胞抗原（PSCA）基因中的多态性与胃癌风险之间的强关联。在本病例对照研究中，我们的目的是验证这种关联，并进一步探讨环境因素可能与PSCA多态性在708例胃癌病例和708例年龄性别匹配的对照中相互作用。PSCA多态性与幽门螺杆菌感染之间的关联也进行了研究。我们发现rs 2294008和rs 2976392与胃癌风险显著相关，这两个基因彼此紧密连锁（D' = 1.00）。rs 2994008的每个等位基因比值比为1.40（95%置信区间：1.19-1.65; p = 3.7 x 10（-5））。我们发现一级亲属中胃癌家族史有显著的相互作用（P异质性= 0.009）。与最初报道的相关性相似，我们发现弥漫型和肠型之间存在显著异质性（p异质性= 0.007）。PSCA多态性与H.幽门感染总之，PSCA多态性与日本人胃癌风险相关。与家族史可能的相互作用需要进一步评估。(C)2009年UICC
A recent whole-genome association study identified a strong association between polymorphisins in the prostate stem cell antigen (PSCA) gene and stomach cancer risk. In this case-control study, we aimed to validate this association, and further to explore environmental factors possibly interacting with PSCA polymorphisms in 708 incident stomach cancer cases and 708 age-sex matched controls. The association between PSCA polymorphisms and Helicobacter pylori infection was also examined. We found that rs2294008 and rs2976392, which were strongly linked to each other (D' = 1.00), were significantly associated with stomach cancer risk. Per allele odds ratio for rs2994008 was 1.40 (95% confidence interval: 1.19-1.65; p = 3.7 x 10(-5)). We found significant interaction with a family history of stomach cancer in first-degree relatives (P-heterogeneity = 0.009). Similar to originally reported association, we found significant heterogeneity between diffuse and intestinal type (p-heterogeneity = 0.007). No association was seen between PSCA polymorphisms and H. pylori infection. In conclusion, PSCA polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation. (C) 2009 UICC