astray, a zebrafish roundabout homolog required for retinal axon guidance
astray, a zebrafish roundabout homolog required for retinal axon guidance
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DOI：
10.1126/science.1059496
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发表时间：
2001-04-20
期刊：
影响因子：
56.9
通讯作者：
Chien, CB
中科院分区：
文献类型：
--
作者：
Fricke, C;Lee, JS;Chien, CB
当生长的视网膜顶盖轴突从眼睛导航到顶盖时，它们感受到沿着视路分布的引导分子。斑马鱼误入歧途基因的突变严重破坏视网膜轴突导向，导致前后路径寻找缺陷，过度中线交叉和视网膜投射的去束。眼移植实验表明，眼睛需要误入歧途功能。我们将误入歧途识别为斑马鱼robo2，轴突导向受体Roundabout家族的成员。视网膜神经节细胞在延伸轴突时表达robo2。因此，在建立脊椎动物视觉投射期间，需要robo2用于多个轴突指导决策。
As growing retinotectal axons navigate from the eye to the tectum, they sense guidance molecules distributed along the optic pathway. Mutations in the zebrafish astray gene severely disrupt retinal axon guidance, causing anterior-posterior pathfinding defects, excessive midline crossing, and defasciculation of the retinal projection, Eye transplantation experiments show that astray function is required in the eye, We identify astray as zebrafish robo2, a member of the Roundabout family of axon guidance receptors. Retinal ganglion cells express robo2 as they extend axons. Thus, robo2 is required for multiple axon guidance decisions during establishment of the Vertebrate visual projection.