One-Pot Synthesis of Isocyanides from Alcohols
One-Pot Synthesis of Isocyanides from Alcohols
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DOI：
10.1055/s-0031-1289592
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发表时间：
2011-12-01
影响因子：
2.6
通讯作者：
Kitano, Yoshikazu
中科院分区：
文献类型：
--
作者：
Okada, Iku;Kitano, Yoshikazu
由醇与三甲基硅氰和甲磺酸进行一锅反应，然后用三乙胺中和，再用甲苯酰氯和吡啶脱水，制得相应的异氰化物，收率中高。用该方法以相应的醇为原料合成叔异氰酸酯和苯基异氰酸酯。
A one-pot reaction of alcohols with trimethylsilyl cyanide and methanesulfonic acid with subsequent neutralization by triethylamine and dehydration by tosyl chloride and pyridine gave the corresponding isocyanides in moderate-to-high yields. This method was used to synthesize tertiary and benzylic isocyanides from the corresponding alcohols.