SUSCEPTIBILITY OF HUMAN HERPESVIRUS-6 TO ANTIVIRALS INVITRO
SUSCEPTIBILITY OF HUMAN HERPESVIRUS-6 TO ANTIVIRALS INVITRO
复制标题
DOI：
10.1093/infdis/162.3.634
复制
发表时间：
1990-09-01
影响因子：
6.4
通讯作者：
SANDFORD, GR
中科院分区：
文献类型：
--
作者：
BURNS, WH;SANDFORD, GR
人疱疹病毒6 （HHV-6）是从淋巴样细胞中分离出来的一种新发现的人疱疹病毒，被认为是引起外耳炎的病原体。采用斑点杂交技术，比较了HHV-6与1型单纯疱疹病毒和人巨细胞病毒对几种抗病毒药物的敏感性。HHV-6与巨细胞病毒最相似的是，它对阿昔洛韦和溴酰脱氧尿苷的抗病毒作用相对耐药，但对更昔洛韦和膦乙酸敏感。从这些结果来看，更有可能HHV-6感染对更昔洛韦和氟膦酸酯的反应比对阿昔洛韦的反应更有可能，尽管阿昔洛韦的低毒性可能允许其在可能影响HHV-6复制的剂量下使用。
Human herpesvirus 6 (HHV-6) is a recently recognized human herpesvirus isolated from lymphoid cells and thought to be the causative agent for exanthem sibitum. Using dot blot hybridization, the HHV-6 sensitivity pattern to several antivirals was compared with those of herpes simplex virus type 1 and human cytomegalovirus. HHV-6 most closely resembled cytomegalovirus in that it was relatively resistant to the antiviral effects of acyclovir and bromovinyl-deoxyuridine but sensitive to ganciclovir and phosphonoacetic acid. From these results, it appears more likely that HHV-6 infections would respond to ganciclovir and foscarnet than to acyclovir should treatment be deemed advisable, although the low toxicity of acyclovir may allow for its use at doses that might affect replication of HHV-6.