PITUITARY MAGNETIC-RESONANCE-IMAGING IN NORMAL HUMAN VOLUNTEERS - OCCULT ADENOMAS IN THE GENERAL-POPULATION
PITUITARY MAGNETIC-RESONANCE-IMAGING IN NORMAL HUMAN VOLUNTEERS - OCCULT ADENOMAS IN THE GENERAL-POPULATION
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DOI：
10.7326/0003-4819-120-10-199405150-00001
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发表时间：
1994-05-15
影响因子：
39.2
通讯作者：
OLDFIELD, EH
中科院分区：
文献类型：
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作者：
HALL, WA;LUCIANO, MG;OLDFIELD, EH
目的：确定无症状人群中提示垂体腺瘤存在的垂体局灶性病变的患病率。设计：100名正常志愿者研究对象（70名女性，30名男性;年龄范围，18至60岁）在给予钆-二乙烯三胺五乙酸（Gd-DTPA）之前和之后通过垂体的高分辨率磁共振成像（MRI）进行研究。在3%-27%的无症状垂体腺瘤患者中，尸检时发现了隐匿性垂体腺瘤。偶然的垂体腺瘤的MRI检测在正常persons.Measurements的频率是未知的：从志愿者的MRI扫描随机混合扫描的57例库欣病和解释独立的三个盲reviewers.Results：七名妇女（10%）和三名男子（10%）有局灶性区域的信号强度降低后，在垂体给药的Gd-DTPA。病变最大直径范围为3 - 6 mm，3名评审员中至少有2名将其诊断为垂体腺瘤。当库欣病患者的MRI扫描发现类似病变时，该部位腺瘤的阳性预测值为86%。结论：大约10%的正常成人MRI扫描显示垂体异常，与无症状垂体腺瘤的诊断一致。大多数垂体腺瘤无症状，不需要治疗。
Objective: To determine the prevalence of focal lesions of the pituitary gland that suggest the presence of a pituitary adenoma in asymptomatic persons.Design: 100 normal volunteers (70 women, 30 men; age range, 18 to 60 years old) were studied by high-resolution magnetic resonance imaging (MRI) of the pituitary gland before and after administration of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA).Setting: Occult pituitary adenomas are identified at autopsy in 3% to 27% of unselected asymptomatic patients. The frequency of incidental pituitary adenomas detected by MRI in normal persons is unknown.Measurements: The MRI scans from volunteers were randomly mixed with scans of 57 patients with Cushing disease and interpreted independently by three blinded reviewers.Results: Seven women (10%) and three men (10%) had focal areas of decreased signal intensity in the pituitary gland after administration of Gd-DTPA. The lesions ranged from 3 to 6 mm in greatest diameter and were diagnosed as pituitary adenomas by at least two of the three reviewers. When similar lesions were detected on MRI scans in patients with Cushing disease, the positive predictive value for identification of an adenoma at that site was 86%.Conclusions: About 10% of the normal adult population have pituitary abnormalities on MRI scans that are compatible with the diagnosis of asymptomatic pituitary adenomas. Most pituitary adenomas remain asymptomatic and do not require treatment.