Adiponectin concentration and insulin indicators following overfeeding in identical twins.
Adiponectin concentration and insulin indicators following overfeeding in identical twins.
复制标题
同卵双胞胎过度喂养后的脂联素浓度和胰岛素指标。
DOI：
10.1007/bf03345579
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发表时间：
2008
影响因子：
5.4
通讯作者：
Bouchard,C
中科院分区：
文献类型：
--
作者：
Ukkola,O;Terán-García,M;Tremblay,A;Després,J-P;Bouchard,C
低脂联素水平与高体重指数、低胰岛素敏感性和糖尿病相关。 目的：评估同卵双胞胎长期过度喂养时血清脂联素浓度变化与肥胖、血糖和胰岛素之间的关系，并计算双胞胎血清脂联素浓度的相似性。 受试者和设计：24 名久坐的年轻男性 [平均 (±SD) 年龄，21±2 岁]研究了 12 对健康同卵双胞胎对过度喂养的代谢和脂联素变化。干预：受试者在 100 天内过量喂养 84,000 kcal。结果测量：过度喂养研究提供了一个机会来检查脂联素与体重、肥胖、血浆葡萄糖和胰岛素变化之间的关系。结果：血清脂联素浓度与体重呈正相关（r= 0.41，p=0.05）在基线，但没有肥胖指标或内脏脂肪。基线脂联素浓度与体重或过度喂养引起的肥胖增加之间不存在关系。然而，由于过度喂养，血清脂联素显着降低-2.35±0.48 μg/ml (p=0.001)。基线脂联素水平与血浆空腹血糖水平（r=-0.53，p=0.01）和稳态模型评估指数（r=-0.41，p=0.05）的变化呈负相关，与脂肪量无关。双胞胎相似度的配对内系数 (r=0.75，p=0.001) 强烈表明基线血清脂联素浓度是一种家族性状。 结论：这些数据提供的证据表明脂联素浓度是正常体重个体的一种家族性状，当受到正能量平衡挑战时脂联素浓度会降低，并且过度喂养引起的变化与葡萄糖和胰岛素水平相关。
Low adiponectin levels have been associated with high body mass index, low insulin sensitivity, and diabetes.Objective: To assess the relationships between changes in serum adiponectin concentration and adiposity, glucose, and insulin in response to long-term overfeeding in identical twins and to calculate the twin resemblance in serum adiponectin concentrations.Subjects and design: Twenty-four sedentary young men [mean (±SD) age, 21±2 yr] who constituted 12 pairs of healthy identical twins were studied for metabolic and adiponectin changes in response to overfeeding.Intervention: Subjects were overfed by 84,000 kcal over a 100-day period.Outcome measures: The overfeeding study provides an opportunity to examine the relationships between adiponectin and changes in body weight, adiposity, plasma glucose and insulin.Results: Serum adiponectin concentration correlated positively with body weight (r= 0.41,p=0.05) at baseline but not with indicators of adiposity or with visceral fat. No relationship existed between baseline adiponectin concentration and body weight or adiposity gains with overfeeding. However, serum adiponectin decreased significantly by −2.35±0.48 μg/ml (p=0.001) in response to overfeeding. Baseline adiponectin levels correlated negatively with changes in plasma fasting glucose levels (r=−0.53,p=0.01) and homeostasis model assessment index (r=−0.41,p=0.05), independently of fat mass. The intrapair coefficient for twin resemblance (r=0.75,p=0.001) strongly suggests that baseline serum adiponectin concentration is a familial trait.Conclusions: These data provide evidence that adiponectin concentration is a familial trait in normal-weight individuals, that it decreases when challenged by positive energy balance, and that its overfeeding-induced variations are correlated with glucose and insulin levels.