EARLY RESTRICTION OF THE HUMAN-ANTIBODY REPERTOIRE
EARLY RESTRICTION OF THE HUMAN-ANTIBODY REPERTOIRE
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DOI：
10.1126/science.3118465
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发表时间：
1987-11-06
期刊：
影响因子：
56.9
通讯作者：
PERLMUTTER, RM
中科院分区：
文献类型：
--
作者：
SCHROEDER, HW;HILLSON, JL;PERLMUTTER, RM
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Diversification of the antibody repertoire in mammals results from a series of apparently random somatically propagated gene rearrangement and mutational events. Nevertheless, it is well known that the adult repertoire of antibody specificities is acquired in a developmentally programmed fashion. As previously shown, rearrangement of the gene segments encoding the heavy-chain variable regions (VH) of mouse antibodies is also developmentally ordered: the number of VH gene segments rearranged in B lymphocytes of fetal mice is small but increases progressively after birth. In this report, human fetal B-lineage cells were also shown to rearrange a highly restricted set of VH gene segments. In a sample of heavy-chain transcripts from a 130-day human fetus the most frequently expressed human VH element proved to be closely related to the VH element most frequently expressed in murine fetal B-lineage cells. These observations are important in understanding the development of immunocompetence.