Cu2+ -mediated assembly of the minor groove binders on the DNA template with sequence selectivity.
Cu2+ -mediated assembly of the minor groove binders on the DNA template with sequence selectivity.
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DOI：
10.1021/ol060632b
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发表时间：
2006-06
期刊：
影响因子：
5.2
通讯作者：
M. Tanada;Saori Tsujita;T. Kataoka;S. Sasaki
中科院分区：
文献类型：
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作者：
M. Tanada;Saori Tsujita;T. Kataoka;S. Sasaki
配体（Bpy-H, 5）被设计用于连接Hoechst33258骨架进行DNA结合和连接2,2'-联吡啶进行Cu（2+）络合。研究表明，具有长连接体的新型Hoechst配体长bppy - h （5L）在具有两个a (3)T(3)位点的DNA模板上选择性地表现出Cu（2+）介导的组装，这取决于配体连接体的长度以及DNA两个a (3)T(3)位点之间的距离。[反应：见正文]
The ligands (Bpy-H, 5) have been designed to connect the Hoechst33258 skeleton for DNA binding and 2,2'-bipyridine for Cu(2+) complexation. It has been revealed that the new Hoechst ligand long Bpy-H (5L) having a long linker exhibits Cu(2+)-mediated assembly on the DNA template having two A(3)T(3) sites in a selective manner depending on the length of the linker of the ligand as well as on the distance between the two A(3)T(3) sites of DNA. [reaction: see text]