Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 With Atrial Fibrillation in a Taiwanese Population
Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 With Atrial Fibrillation in a Taiwanese Population
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DOI：
10.1253/circj.cj-11-0525
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发表时间：
2012-01-01
影响因子：
3.3
通讯作者：
Tsai, Chia-Ti
中科院分区：
文献类型：
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作者：
Chang, Shu-Hsuan;Chang, Sheng-Nan;Tsai, Chia-Ti
背景：最近一项对欧洲血统个体的研究表明，染色体1q21上钾离子中/小电导钙激活通道亚家族N成员3(KCNN3)的单核苷酸多态(SNP)rs13376333与孤立性心房颤动(房颤)显著相关，这表明房颤的共同遗传基础。方法与结果：采用病例对照设计，比较了214例单纯性房颤患者(58.3+/-11.4岁)和214例对照组(57.7+/-13.2岁)和322例结构性房颤患者(69.6+/-13.7岁)和322例对照组(68.4+/-14.2岁)的SNP rs13376333。KCNN3的SNP rs13376333与结构性或孤立性房颤显著相关。孤立性房颤组rs13376333等位基因频率为8.6%，对照组为3.0%，差异有统计学意义(P
Background: A recent study in individuals of European ancestry demonstrated a significant association of the single nucleotide polymorphism (SNP) rs13376333 in potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (KCNN3) on chromosome 1q21 with lone atrial fibrillation (AF), indicating a common genetic basis for AF. The aim of the present study was to investigate whether this association between SNP rs13376333 and AF also exists in Taiwanese subjects.Methods and Results: The SNP rs13376333 was compared in 214 lone AF patients (58.3 +/- 11.4 years) vs. 214 controls (57.7 +/- 13.2 years), and in 322 structural AF patients (69.6 +/- 13.7 years) vs. 322 controls (68.4 +/- 14.2 years) in a Taiwanese population, in a case control design. The associations between SNP rs13376333 in KCNN3 and structural or lone AF were significant. In the lone AF group, the frequency of the minor allele of SNP rs13376333 was 8.6% compared with 3.0% in the controls (P