Effects of lower-leg rhythmic cuff inflation on cardiovascular autonomic responses during quiet standing in healthy subjects
Effects of lower-leg rhythmic cuff inflation on cardiovascular autonomic responses during quiet standing in healthy subjects
复制标题
DOI：
10.1152/ajpheart.01288.2010
复制
发表时间：
2011-05-01
影响因子：
4.8
通讯作者：
Uchida, Katsuo
中科院分区：
文献类型：
--
作者：
Niizeki, Kyuichi;Tominaga, Takanori;Uchida, Katsuo
Niizeki K, Tominaga T, Saitoh T, Nishidate I, Takahashi T, Uchida K.健康受试者安静站立时小腿节律性袖带膨胀对心血管自主反应的影响。[J]中国生物医学工程学报，2011,31(2):559 - 559。首次发表于2011年3月4日；doi: 10.1152 / ajpheart.01288.201.0。为了确定静站立时肌泵功能对心脏自主神经活动的影响，我们通过下肢袖带节律性充气（RCI）模拟了肌肉泵的作用，在5个周期/分钟的情况下，用4个袖带压力分别为0（假手术）、40、80和120 mmHg。测量健康受试者（男性6例，女性5例，年龄21 ~ 24岁）的R-R间期（RRI）和搏动血压（BP）。从连续测得的BP数据出发，采用脉冲轮廓法计算冲程体积（SV）。通过光谱和交叉光谱分析，估计了低频段和高频频段的RRI和收缩压变异性以及自发性心脏压力反射敏感性（sBRS）的增益。与假手术条件比较。当袖带压力为80和120 mmHg时，静站立时平均RRI升高（P < 0.01）， RRI波动的HE功率升高（80 mmHg时P < 0.05, 120 mmHg时P < 0.01）。站立时SV的减少被抑制，站立时HP带的sBRS随袖带压力的RCI而增加（80 mmHg时P < 0.05, 120 mmHg时P < 0.01），然而，在40 mmHg RCI时，这些保持不变。这些结果表明，在站立时。当袖带压力升高到足以对抗流体静力引起的小腿静脉压力时，小腿RCI增加心脏迷走神经流出。
Niizeki K, Tominaga T, Saitoh T, Nishidate I, Takahashi T, Uchida K. Effects of lower-leg rhythmic cuff inflation on cardiovascular autonomic responses during quiet standing in healthy subjects. Am J Physiol Heart Circ Physiol 300: H1923-H1929, 2011. First published March 4, 2011; doi:10.1152/ajpheart.01288.201.0.-To determine the effects of muscle pump function on cardiac autonomic activity in response to quiet standing, we simulated the muscle pump effect by rhythmic lower-leg cuff inflation (RCI) with four cuff pressures of 0 (sham), 40, 80, and 120 mmHg at 5 cycles/min. The R-R interval (RRI) and beat-to-beat blood pressure (BP) were acquired in healthy subjects (6 males and 5 females, aged 21-24 yr). From the continuous BP measurement, stroke volume (SV) was calculated by a pulse-contour method. Using spectral and cross-spectral analysis, RRI and systolic BP variability as well as the gain of spontaneous cardiac baroreflex sensitivity (sBRS) were estimated for the low- and high-frequency (HF) bands. Compared with the sham condition. RCI with cuff pressures of 80 and 120 mmHg led to increases in the mean RRI (P < 0.01) and HE power of RRI fluctuation (P < 0.05 for 80 mmHg and P < 0.01 for 120 mmHg) during quiet standing. Reduction in SV during standing was suppressed, and the sBRS of the HP band for standing were increased by RCI for either cuff pressure (P < 0.05 for 80 mmHg and P < 0.01 for 120 mmHg) However, at 40 mmHg RCI, these remained unchanged. These results suggest that, during standing. RCI of the lower leg increases cardiac vagal outflow when the cuff pressure is raised enough to oppose the hydrostatic-induced venous pressure in the calf.