MECHANISM OF EGG-SYNCHRONIZING ACTION OF SEROTONIN
MECHANISM OF EGG-SYNCHRONIZING ACTION OF SEROTONIN
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DOI：
10.1152/ajplegacy.1966.211.4.926
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发表时间：
1966-01-01
影响因子：
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通讯作者：
CZICMAN, J
中科院分区：
文献类型：
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作者：
KOELLA, WP;CZICMAN, J
在用Dial和尿素脲麻醉的猫中，或用亚拉西地尔治疗并以1/10手术剂量的Dial和尿素脲镇静的猫中，颈动脉内注射血清素（0.2-5.0 [mu]g/kg体wt）诱导初始唤醒模式，在30-150秒后被持续时间长达15分钟的长时间高同步期所取代。内侧丘脑刺激产生的招募反应对血清素表现出类似的双相反应，其特征是最初的抑郁，随后往往是显著的和持久的增强。这些脑电图变化伴随着瞳孔最初扩大然后缩小。在脑干的脑桥中段横断后，血清素只在脑电图中产生兴奋的迹象。椎体内注射5-HT[5-羟色胺]和第4脑室注射5-HT仅引起超同步效应。后脑区烧灼或后第四脑室应用5-HT阻滞剂后，颈动脉内或椎体内5-HT的超同步效应减少或完全消除。由此得出结论，血清素通过作用于睡眠后区域的受体部位而产生同步睡眠的脑电图和眼部信号，神经信号从该区域传递到孤立束核，然后再传递到更靠近眼侧的催眠区。
In cats anesthetized with Dial and urethan, or treated with Flaxedil and sedated with 1/10 surgical dose of Dial and urethan, intracarotid injection of serotonin (0.2-5.0 [mu]g/kg body wt) induced an initial arousal pattern replaced after 30-150 sec by a protracted phase of hypersynchrony which lasted often as long as 15 min. Recruiting responses produced by medial thalamlc stimulation showed a similar biphasic reaction to serotonin characterized by initial depression followed by often marked and long-lasting enhancement. These eeg changes were accompanied by initial widening then narrowing of the pupils. After transection of the brain stem at the midpontine level, serotonin produced only signs of arousal in the eeg. Intravertebral injections of 5-HT [5-Hydroxytryptamine] and injections of 5-HT into the 4th ventricle induced only hypersynchronizing effects. After cauterization of the area postrema or after application of 5-HT blocking agents to the posterior 4th ventricle the hypersynchronizing effects of intracarotid or intravertebral 5-HT were reduced or altogether eliminated. It is concluded that serotonin produces the eeg and ocular signs of synchronized sleep by an action exerted on receptor sites in the area postrema, from which nervous signals travel to the nucleus of the solitary tract and then to more rostrally situated hypnogenic areas.