Meningoencephalitis as an initial manifestation of neuromyelitis optica spectrum disorder
Meningoencephalitis as an initial manifestation of neuromyelitis optica spectrum disorder
复制标题
脑膜脑炎是视神经脊髓炎谱系疾病的首发表现
DOI：
10.1177/1352458512459785
复制
发表时间：
2013-04-01
影响因子：
5.8
通讯作者：
Luo, Ben-Yan
中科院分区：
文献类型：
--
作者：
Wang, Jin-Ye;Wang, Kai;Luo, Ben-Yan
2例患者首发症状为头痛、发热，2周后出现意识障碍。脑脊液（CSF）呈多胞血症> 500x10(6)/L。磁共振成像（MRI）显示在高水通道蛋白-4 （AQP-4）表达部位出现多处脑损伤。病例1在首次发作后4年出现视神经炎，病例2在头痛后3周出现脊髓炎症状。两例患者血清AQP-4抗体均呈阳性，诊断为视神经脊髓炎频谱障碍（NMOSD）。因此，NMOSD最初可表现为模拟颅内感染的脑膜脑炎，其特征性MRI影像对鉴别非常关键。
Two patients presented with initial symptoms of headache and fever, and two weeks later had disturbance of consciousness. Cerebrospinal fluid (CSF) showed pleocytosis > 500x10(6)/L. Magnetic resonance imaging (MRI) showed multiple brain lesions at sites of high aquaporin-4 (AQP-4) expression. Case 1 presented optic neuritis four years after the first attack and case 2 had symptoms of myelitis three weeks after headache. Serum AQP-4 antibody was positive in both cases, and the diagnosis of neuromyelitis optica spectrum disorder (NMOSD) was made. Accordingly, NMOSD can initially present as meningoencephalitis mimicking intracranial infection, and the characteristic MRI imaging is quite critical for differentiation.