Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy
Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy
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DOI：
10.1016/s0002-9610(02)01012-7
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发表时间：
2002-11-01
影响因子：
3
通讯作者：
Singletary, SE
中科院分区：
文献类型：
--
作者：
Singletary, SE
背景：接受保乳治疗的患者存在局部复发的终身风险。为了将这种风险降至最低，外科医生已经探索了多种检查切除标本手术切缘的方法。如果在切缘发现肿瘤细胞，那么手术腔内很可能残留肿瘤。本综述研究了已发表的关于评估手术切缘的标准和创新方法、切缘大小的临床意义以及切缘阳性的风险因素的报告。
方法：使用美国国立医学图书馆的网关网站对在医学文献数据库（Medline）中提取的已发表文献进行了综述。
结论：目前仍不清楚获得根治性切缘是否会降低保乳手术后的局部复发率。但明确的是，无论术后辅助治疗的类型如何，在切除标本的切割边缘直接存在肿瘤细胞是绝对不可接受的。（C）2002爱思唯尔公司。版权所有。
Background: Patients receiving breast conservation therapy have a lifelong risk of local recurrence. To minimize this risk, surgeons have explored various approaches to examining the surgical margins of the resection specimen. If tumor cells are found at the margin, there is a high probability that residual tumor remains in the surgical cavity. This review examines published reports about standard and innovative approaches to assessing surgical margins, the clinical significance of margin size, and risk factors for positive margins.Methods: Published literature abstracted in Medline was reviewed using the Gateway site from the National Library of Medicine.Conclusions: It is still not clear whether obtaining a radical margin will decrease the rate of local recurrence after breast conserving surgery. What is clear is that it is absolutely unacceptable to have tumor cells directly at the cut edge of the excised specimen, regardless of the type of post-surgical adjuvant therapy. (C) 2002 Excerpta Medica Inc. All rights reserved.