New γ-Lactone Carboxylic Acids from the Lichen Parmotrema praesorediosum ( Nyl . ) Hale , Parmeliaceae
New γ-Lactone Carboxylic Acids from the Lichen Parmotrema praesorediosum ( Nyl . ) Hale , Parmeliaceae
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来自 Parmeliaceae 地衣 Parmotrema praesorediosum (Nyl.) Hale 的新 γ-内酯羧酸
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发表时间：
2015
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通讯作者：
K. Nguyen
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作者：
B. Huynh;T. Duong;T. Do;T. George;Pinnock;L. M. Pratt;Shigeki Yamamoto;H. Watarai;T. Tanahashi;K. Nguyen
从地衣Parmotrema praesorediosum（Nyl.）黑尔，Parmeliaceae，越南产，分离得到5个新的（1，2，3，5，6）和1个已知的（4）β-内酯酸。新化合物的结构通过1D和2D NMR光谱以及高分辨率电喷雾电离（HR-ESI）-MS分析确定。用紫外圆二色谱法测定了新化合物的绝对构型。评价化合物在100 μg/mL浓度下对HeLa（人上皮癌）、NCI-H460（人肺癌）和MCF-7（人乳腺癌）细胞系的细胞毒性活性。在6个化合物中，1个化合物对MCF-7细胞的抑制率为52.5%，具有中等的抑制活性。同时，其余的对三种调查的癌细胞系没有显示出细胞毒活性。
From the lichen Parmotrema praesorediosum (Nyl.) Hale, Parmeliaceae, collected in Vietnam, five new (1, 2, 3, 5, 6) and one known (4) -lactonic acids were isolated. The structures of the new compounds were established by 1D and 2D NMR spectroscopy, as well as high resolution-electrospray ionization (HR-ESI)-MS analysis. The absolute configuration of new compounds was determined by ultraviolet circular dichroism spectroscopy. Compounds were evaluated for their cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer) and MCF-7 (human breast cancer) cell lines at the concentration of 100 μg/mL. Among six compounds, 1 possessed medium activity against MCF-7 cell line with the inhibition of 52.5%. Meanwhile, the rest showed no cytotoxic activity against three surveyed cancer cell lines.
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