Single-heartbeat cardiac cine imaging via jointly regularized nonrigid motion-corrected reconstruction
Single-heartbeat cardiac cine imaging via jointly regularized nonrigid motion-corrected reconstruction
复制标题
通过联合正则化非刚性运动校正重建的单心跳心脏电影成像
DOI：
10.1002/nbm.4942
复制
发表时间：
2023
影响因子：
2.9
通讯作者：
Cruz G
中科院分区：
文献类型：
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作者：
Cruz G
本研究的目的是通过结合心脏运动校正重建和非刚性对齐的基于补丁的正则化，开发一种用于单次心跳的2D屏气心脏电影成像的新方法。常规心脏电影成像是通过多次心跳采集的数据的运动分辨重建获得的。在这里，我们通过将非刚性心脏运动校正结合到每个心脏相位的重建中，结合基于运动对齐的补丁正则化，实现单心跳电影成像。申报的运动校正CINE（MC‐CINE）将所有采集的数据合并到每个（运动校正）心动时相的重建中，从而产生比运动分辨方法更好的问题。在14名健康受试者中，在图像清晰度、阅片人评分（范围：1-5）和图像质量阅片人评级（范围：1-9）以及单层左心室评估方面，比较了MC‐CINE与迭代灵敏度编码（itSENSE）和额外维度黄金角径向稀疏平行（XD‐GRASP）。使用20次心跳、两次心跳和一次心跳时，MC‐CINE显著上级itSENSE和XD‐GRASP。Iterative SENSE、XD-GRASP和MC-CINE在20次心跳时分别实现了74%、74%和82%的清晰度，在1次心跳时分别实现了53%、66%和82%的清晰度。读片员评分的相应结果分别为4.0、4.7和4.9（20次心跳），1.1、3.0和3.9（1次心跳）。20次心跳的阅片者评级的相应结果分别为5.3、7.3和8.6，1次心跳的相应结果分别为1.0、3.2和5.4。使用单次心跳的MC-CINE与itSENSE（20次心跳）的图像质量无显著差异。相对于参考itSENSE，一次心跳时的MC-CINE和XD-GRASP在射血分数方面均呈现小于2%的非显著负偏差。得出的结论是，相对于itSENSE和XD‐GRASP，申报的MC‐CINE显著提高了图像质量，从而实现了单次心跳的2D电影。
The aim of the current study was to develop a novel approach for 2D breath‐hold cardiac cine imaging from a single heartbeat, by combining cardiac motion‐corrected reconstructions and nonrigidly aligned patch‐based regularization. Conventional cardiac cine imaging is obtained via motion‐resolved reconstructions of data acquired over multiple heartbeats. Here, we achieve single‐heartbeat cine imaging by incorporating nonrigid cardiac motion correction into the reconstruction of each cardiac phase, in conjunction with a motion‐aligned patch‐based regularization. The proposed Motion‐Corrected CINE (MC‐CINE) incorporates all acquired data into the reconstruction of each (motion‐corrected) cardiac phase, resulting in a better posed problem than motion‐resolved approaches. MC‐CINE was compared with iterative sensitivity encoding (itSENSE) and Extra‐Dimensional Golden Angle Radial Sparse Parallel (XD‐GRASP) in 14 healthy subjects in terms of image sharpness, reader scoring (range: 1–5) and reader ranking (range: 1–9) of image quality, and single‐slice left ventricular assessment. MC‐CINE was significantly superior to both itSENSE and XD‐GRASP using 20 heartbeats, two heartbeats, and one heartbeat. Iterative SENSE, XD‐GRASP, and MC‐CINE achieved a sharpness of 74%, 74%, and 82% using 20 heartbeats, and 53%, 66%, and 82% with one heartbeat, respectively. The corresponding results for reader scoring were 4.0, 4.7, and 4.9 with 20 heartbeats, and 1.1, 3.0, and 3.9 with one heartbeat. The corresponding results for reader ranking were 5.3, 7.3, and 8.6 with 20 heartbeats, and 1.0, 3.2, and 5.4 with one heartbeat. MC‐CINE using a single heartbeat presented nonsignificant differences in image quality to itSENSE with 20 heartbeats. MC‐CINE and XD‐GRASP at one heartbeat both presented a nonsignificant negative bias of less than 2% in ejection fraction relative to the reference itSENSE. It was concluded that the proposed MC‐CINE significantly improves image quality relative to itSENSE and XD‐GRASP, enabling 2D cine from a single heartbeat.