Towards a molecular definition of keratinocyte activation after acute injury to stratified epithelia
Towards a molecular definition of keratinocyte activation after acute injury to stratified epithelia
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DOI：
10.1006/bbrc.1997.6945
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发表时间：
1997-07-18
影响因子：
3.1
通讯作者：
Coulombe, PA
中科院分区：
文献类型：
--
作者：
Coulombe, PA
虽然近年来我们越来越认识到皮肤的多方面作用，但这些新的贡献可能没有几个世纪前推断的皮肤屏障功能那么重要。在人类皮肤中，这一功能几乎完全由表皮完成，表皮是一种薄层复层扁平上皮，主要由角质形成细胞组成，位于皮肤表面。表皮完整性的破坏会触发涉及血源性成分和常驻皮肤细胞类型的动态平衡反应，旨在快速恢复伤口部位的功能性上皮衬里。本文主要研究创面近端完整皮肤组织中角质形成细胞的募集过程，以参与再上皮化。(C)1997年学术出版社。
While in recent years we have come to increasingly appreciate the multifaceted role of skin, probably none of these novel contributions is as vital as its barrier function, inferred centuries ago. In human skin this function is fulfilled nearly entirely by the epidermis, a thin stratified squamous epithelium made up primarily of keratinocytes and located at the skin surface. Disruption of the integrity of epidermis triggers a homeostatic response involving blood-derived elements and resident skin cell types that is designed to rapidly restore a functional epithelial lining over the wound site. This article is focused on the process of recruitment of keratinocytes from intact skin tissue at the proximal wound edges to participate in re epithelialization. (C) 1997 Academic Press.