The Efficacy and Tolerability of Adjunctive Alternative Herbal Medicine (Salvia miltiorrhiza and Pueraria lobata) on Vascular Function and Structure in Coronary Patients
The Efficacy and Tolerability of Adjunctive Alternative Herbal Medicine (Salvia miltiorrhiza and Pueraria lobata) on Vascular Function and Structure in Coronary Patients
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DOI：
10.1089/acm.2008.0400
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发表时间：
2009-04-01
影响因子：
2.6
通讯作者：
Woo, Kam S.
中科院分区：
文献类型：
--
作者：
Tam, Wing Y.;Chook, Ping;Woo, Kam S.
研究背景：丹参、葛根是治疗心绞痛等心脏病的常用中药。最近的药理学研究表明其治疗价值。评价丹参和葛根在二级预防中的有效性和安全性。方法：100例连续冠状动脉患者（平均年龄58 ± 8岁）随机分为D&G联合治疗组（3g）和安慰剂组（3g）（6粒胶囊）以双盲平行方式持续24周，然后可选的开放标签D&G（1.5 g/天）再持续6个月。使用超声测量肱动脉血流介导的扩张（FMD）和颈动脉内膜中层厚度（IMT）。24周后，与基线相比，两组的血压、血液学和生化特征、叶酸和同型半胱氨酸水平均无显著变化，但两组的低密度脂蛋白（LDL）胆固醇均轻度降低（p
Background: Danshen and gegen (D&G) have long been used in treatment of angina and other cardiac symptoms in Chinese materia medica. Recent pharmacological studies suggest their therapeutic values. We aimed to evaluate the efficacy and safety of Salvia miltiorrhiza (danshen) and Pueraria lobata (gegen) in secondary prevention.Methods: One hundred (100) consecutive coronary patients (mean age 58 +/- 8 years) were randomized to adjunctive treatment with D&G combination (3 g) or placebo (6 capsules) for 24 weeks in double-blind parallel fashion, followed by optional open-label D&G (1.5 g/day) for 6 more months. Brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) were measured using ultrasound.Results: Baseline characteristics were similar between the 2 groups. After 24 weeks and compared with baseline, there were no significant changes in blood pressures, blood hematological and biochemical profiles, or folate and homocysteine levels in both groups, but there was a mild decrease in low density lipoprotein (LDL) cholesterol in both groups (p