THE ROLE OF THE LIMBIC SYSTEM IN EXPERIENTIAL PHENOMENA OF TEMPORAL-LOBE EPILEPSY
THE ROLE OF THE LIMBIC SYSTEM IN EXPERIENTIAL PHENOMENA OF TEMPORAL-LOBE EPILEPSY
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DOI：
10.1002/ana.410120203
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发表时间：
1982-01-01
影响因子：
11.2
通讯作者：
HOROWITZ, S
中科院分区：
文献类型：
--
作者：
GLOOR, P;OLIVIER, A;HOROWITZ, S
在29例难治性颞叶癫痫患者中，有18例报告了在自发性癫痫发作中出现的经验现象或脑刺激诱发的经验现象。这些现象主要包括知觉(视觉或听觉)幻觉或错觉、记忆闪回、熟悉的错觉、强迫思维或情绪。除非癫痫放电或电刺激涉及边缘结构，否则不会发生经验性现象。对于这种现象的发生，癫痫放电或电刺激并不一定涉及到颞叶新皮质。即使对于感性的经验现象也是如此。许多由电刺激引起的经验性反应，特别是当应用于杏仁核时，与电后放电无关。通过癫痫放电或电刺激激活边缘可能会增加由颞叶新皮质处理的知觉和助记数据的情感维度，这可能是赋予它们经验即时性所必需的。
Experiential phenomena occurring in spontaneous seizures or evoked by brain stimulation were reported by 18 of 29 patients with medically intractable temporal lobe epilepsy who were investigated with chronic, stereotaxically implanted intracerebral electrodes. The phenomena mainly consisted of perceptual (visual or auditory) hallucinations or illusions, memory flashbacks, illusions of familiarity, forced thinking, or emotions. Experiential phenomena did not occur unless a seizure discharge or electrical stimulation involved limbic structures. For such phenomena to occur, seizure discharge or electrical stimulation did not have to implicate temporal neocortex. This was true even for perceptual experiential phenomena. Many experiential responses elicited by electrical stimulation, particularly when applied to the amygdala, were not associated with electrical afterdischarge. Limbic activation by seizure discharge or electrical stimulation may add an affective dimension to perceptual and mnemonic data processed by the temporal neocortex, which may be required for endowing them with experiential immediacy.