From Krebs to clinic: glutamine metabolism to cancer therapy.
From Krebs to clinic: glutamine metabolism to cancer therapy.
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DOI：
10.1038/nrc.2016.71
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Dang CV
中科院分区：
文献类型：
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作者：
Altman BJ;Stine ZE;Dang CV
癌症代谢研究的复兴最近将人们的兴趣从葡萄糖和瓦伯格效应扩展到包括谷氨酰胺在内的其他营养素。由于代谢的致癌改变使癌细胞对营养物质上瘾，因此可以利用参与糖酵解或谷氨酰胺分解的途径用于治疗目的。在这篇综述中，我们提供了谷氨酰胺代谢及其在体外和体内肿瘤发生中的作用的最新概述，并探讨了基础科学发现在临床环境中的最新潜在应用。
The resurgence of research in cancer metabolism has recently broadened interests beyond glucose and the Warburg Effect to other nutrients including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.