The Role of Intrinsic Brain Functional Connectivity in Vulnerability and Resilience to Bipolar Disorder.
The Role of Intrinsic Brain Functional Connectivity in Vulnerability and Resilience to Bipolar Disorder.
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DOI：
10.1176/appi.ajp.2017.17010095
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发表时间：
2017-12-01
期刊：
影响因子：
--
通讯作者：
Frangou S
中科院分区：
文献类型：
--
作者：
Doucet GE;Bassett DS;Yao N;Glahn DC;Frangou S
Bipolar disorder is a heritable disorder characterized by mood dysregulation associated with brain functional dysconnectivity. Prior research has focused on the detection of risk- and disease-associated dysconnectivity in individuals with bipolar disorder and their first-degree relatives. The current study seeks to identify adaptive brain connectivity features associated with resilience, defined here as avoidance or delayed illness onset in unaffected siblings of patients with bipolar disorder. Graph theoretical methods were used to examine global and regional brain network topology in head-motion corrected resting-state functional magnetic resonance imaging data acquired from 78 patients with bipolar disorder, 64 unaffected siblings, and 41 healthy volunteers*, mean age 33 years*. Global network properties were preserved in patients and their siblings while both groups showed reduction in the cohesiveness of the sensorimotor network. In patients, these sensorimotor network abnormalities were also coupled with reduced integration of core default-mode network regions in the ventromedial cortex and hippocampus. Conversely, integration of the default-mode network was increased in siblings compared to both patients and healthy volunteers. The authors found that trait-related vulnerability to BD was associated with reduced resting-state cohesiveness of the sensorimotor network in bipolar patients. However, integration of the default-mode network emerged as a key feature differentiating disease expression and resilience between the patients and their siblings. This is indicative of the presence of neural mechanisms that may promote resilience, or at least delay onset.
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