Stereoselective product inhibition of glutathione S-transferase.
Stereoselective product inhibition of glutathione S-transferase.
复制标题
谷胱甘肽 S-转移酶的立体选择性产物抑制。
DOI：
10.1016/s0006-291x(86)80126-7
复制
发表时间：
1986
影响因子：
3.1
通讯作者：
Armstrong,RN
中科院分区：
文献类型：
--
作者：
Chen,WJ;deSmidt,PC;Armstrong,RN
大鼠肝脏谷胱甘肽S转移酶同工酶3-3和4-4被9，10-dihydro-9-glutathionyl-10-hydroxyphenanthrene，1.的非对映异构体立体选择性地抑制。联苯部分在酶-1复合体中的构象与在水溶液中相同，谷胱甘肽和羟基在轴位。同工酶4-4也被1，2-二苯基-L-(S-谷胱甘肽)-2-羟乙烷四种非对映异构体抑制。抑制的立体选择性在所有情况下都是适度的，并且在抑制的类型和KI的大小中都表现得很明显。
Isozymes 3–3 and 4–4 of rat liver glutathione S-transferase are stereo-selectively inhibited by the diastereomers of 9,10-dihydro-9-glutathionyl-10-hydroxyphenanthrene,1. The conformation of the biphenyl moiety is the same in the enzyme —1complex as in aqueous solution with the glutathionyl and hydroxy groups in the axial positions. Isozyme 4–4 is also inhibited by the four diastereomers of 1,2 -diphenyl-l-(S-glutathionyl)-2-hydroxyethane. The stereoselectivity of inhibition is modest in all cases and is manifest in both the type of inhibition as well as the magnitude of Ki.