A key role for the subunit SUR2B in the preferential activation of vascular KATP channels by isoflurane
A key role for the subunit SUR2B in the preferential activation of vascular KATP channels by isoflurane
复制标题
亚基 SUR2B 在异氟烷优先激活血管 KATP 通道中的关键作用
DOI：
10.1038/sj.bjp.0706891
复制
发表时间：
2006
影响因子：
7.3
通讯作者：
H. Nakaya
中科院分区：
文献类型：
--
作者：
H. Fujita;T. Ogura;M. Tamagawa;H. Uemura;Toshiaki Sato;A. Ishida;M. Imamaki;F. Kimura;M. Miyazaki;H. Nakaya
据推测，异氟醚是一种挥发性麻醉剂，通过激活ATP敏感的K+ (KATP)通道而产生血管舒张。然而，没有直接证据表明异氟醚可以激活血管中的KATP通道。本研究探讨异氟醚对血管KATP通道的影响，并与对心脏KATP通道的影响进行比较。
It has been postulated that isoflurane, a volatile anaesthetic, produces vasodilatation through activation of ATP‐sensitive K+ (KATP) channels. However, there is no direct evidence for the activation of vascular KATP channels by isoflurane. This study was conducted to examine the effect of isoflurane on vascular KATP channels and compare it with that on cardiac KATP channels.
影响因子：
56.9
作者：
Shyng, SL;Nichols, CG
通讯作者：
Nichols, CG