The association between genetic polymorphisms of interleukin 23 receptor gene and the risk of rheumatoid arthritis: An updated meta-analysis
The association between genetic polymorphisms of interleukin 23 receptor gene and the risk of rheumatoid arthritis: An updated meta-analysis
复制标题
白细胞介素23受体基因的遗传多态性与类风湿性关节炎风险之间的关联：更新的荟萃分析
DOI：
10.1016/j.clim.2019.108250
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发表时间：
2020-01-01
影响因子：
8.6
通讯作者：
Yu, Hongsong
中科院分区：
文献类型：
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作者：
Du, Juan;Wang, Xin;Yu, Hongsong
本研究旨在探讨白细胞介素23受体（IL 23 R）基因的7个单核苷酸多态性（SNP）是否与类风湿关节炎（RA）易感性相关。使用RevMan 5.3版计算统计数据。本荟萃分析纳入了16篇文章，涉及11，816例RA患者和14，268例健康对照。rs 11209026多态性与白种人RA易感性之间存在显著相关性（AA vs. GG：OR = 1.78，95% CI = 1.02-3.10，P = 0.04; AA vs. AG + GG：OR = 1.77，95% CI = 1.02-3.08，P = 0.04）。此外，我们的结果显示，白细胞介素23受体/rs 10489629的G等位基因在白种人和亚洲人的RA患者中具有显著增加的频率（A与G：OR = 0.92，95%CI = 0.88-0.97，P = 0.002; OR = 0.62，95%CI = 0.44-0.87，P = 0.006）。此外，荟萃分析显示rs 1343151多态性与白人RA易感性之间存在显著相关性（C vs. T：OR = 0.91，95%CI = 0.87-0.96，P =.0004）。我们的Meta分析证实IL 23 R基因可能是RA的易感因素。
This meta-analysis was conducted to confirm whether seven single nucleotide polymorphisms (SNPs) of interleukin-23 receptor (IL23R) gene are associated with rheumatoid arthritis (RA) susceptibility. RevMan version 5.3 was used to calculate statistical data. Sixteen articles involving 11,816 RA patients and 14,268 healthy controls were included in this meta-analysis. A significant association was identified between the rs11209026 polymorphism and RA susceptibility in Caucasians (AA vs. GG: OR = 1.78, 95% CI = 1.02-3.10, P =.04; AA vs. AG + GG: OR = 1.77, 95% CI = 1.02-3.08, P =.04). Additionally, our result showed that the G allele of IL23R/rs10489629 had a significantly increased frequency in RA patients of Caucasians and Asians (A vs. G: OR = 0.92, 95% CI = 0.88-0.97, P =.002; OR = 0.62, 95% CI = 0.44-0.87, P =.006, respectively). Furthermore, the meta-analysis revealed a significant association between the rs1343151 polymorphism and RA susceptibility in Caucasians (C vs. T: OR = 0.91, 95% CI = 0.87-0.96, P =.0004). Our meta-analysis confirmed the IL23R gene might be treated as a susceptible factor for RA.