A comparison of symptom determinants of patient and clinician global ratings in patients with panic disorder and depression.
A comparison of symptom determinants of patient and clinician global ratings in patients with panic disorder and depression.
复制标题
恐慌症和抑郁症患者的患者和临床医生总体评级的症状决定因素的比较。
DOI：
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发表时间：
1993
影响因子：
2.9
通讯作者：
I. Goldenberg
中科院分区：
文献类型：
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作者：
Andrew C. Leon;M. Shear;G. Klerman;L. Portera;Jerrold F. Rosenbaum;I. Goldenberg
临床总体印象（CGI）是一种标准的评估工具，通常在精神药理学试验中对变化表现出良好的敏感性。然而，尚未进行系统评估，以确定评级决定是如何作出的。在这篇文章中，我们研究了116例符合DSM-III-R标准的惊恐障碍和抑郁症患者的症状学与CGI严重程度和改善评级之间的关系。预期性焦虑和抑郁评分与CGI项目显著相关。惊恐发作的频率始终与临床医生的严重程度评级相关，但仅与临床医生和患者改善评级零星相关。这些发现在治疗过程中相当一致。我们对CGI的症状决定因素的实证研究表明，它似乎被系统地使用，但全球评级不仅仅是一个复合物。它在临床试验中的广泛应用是有充分理由的。
The Clinical Global Impression (CGI) is a standard assessment tool that generally shows good sensitivity to change in psychopharmacology trials. However, systematic assessment has not been conducted to determine how rating decisions are made. In this article, we examine the relationship between syndromal symptomatology and the CGI severity and improvement ratings in a study of 116 patients who met DSM-III-R criteria for both Panic Disorder and Depression. Anticipatory anxiety and depression ratings were significantly associated with each CGI item. Frequency of panic attacks was consistently related to the clinician's rating of severity but was only sporadically related to the clinician and patient improvement ratings. These findings are fairly consistent during the course of treatment. Our empirical examination of symptom determinants of the CGI demonstrates that it appears to be used systematically, yet global ratings are not merely a composite of symptomatology. Its widespread application in clinical trials is well justified.