Neurotrophins: A link between airway inflammation and airway smooth muscle contractility in asthma?
Neurotrophins: A link between airway inflammation and airway smooth muscle contractility in asthma?
复制标题
DOI：
10.1159/000024056
复制
发表时间：
1999-02-01
影响因子：
2.8
通讯作者：
Renz, H
中科院分区：
文献类型：
--
作者：
Braun, A;Lommatzsch, M;Renz, H
背景资料：支气管哮喘（BA）的特征是一种独特类型的气道炎症，上皮细胞损伤和气道平滑肌（ASM）收缩性增加。免疫事件和神经元控制ASM收缩性之间的调节网络仍有待确定。研究方法：利用表征良好的气道炎症和BA小鼠模型，我们分析了过敏性哮喘中神经营养素的产生和功能。为了证实这些数据在人类中，部分过敏原激发进行轻度哮喘，结果：过敏原诱导的气道炎症与增加的神经营养因子神经生长因子（NGF）和脑源性神经营养因子（BDNF）在小鼠和人类的本地生产。在支气管肺泡灌洗液（BALF）中，过敏原激发后1天，人和小鼠的NGF水平增加了4- 5倍。在两种模型中，BDNF的增加约为2倍。用抗NGF治疗小鼠可防止气道高反应性（AHR）的发展。在人类研究组中，变应原激发后BALF中的NGF水平与基线FEV 1水平显著相关。结论：这些数据有力地表明，神经营养因子作为一个链接之间的气道炎症和神经元控制的ASM收缩在BA。
Background: Bronchial asthma (BA) is characterized by a unique type of airway inflammation, epithelial cell damage and increased airway smooth muscle (ASM) contractility. The regulatory network between the immunological events and the neuronal control of ASM contractility remains to be defined. Methods: Utilizing a well-characterized mouse model of airway inflammation and BA, we analyzed the production and function of neurotrophins in allergic asthma. To confirm these data in humans, segmental allergen provocation was performed in mild asthmatics, Results: Allergen-induced airway inflammation was associated with increased local production of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in mice as well as in humans. In bronchoalveolar lavage fluid (BALF), NGF levels were increased 4- to 5-fold in men and mice 1 day after allergen provocation. The increase in BDNF was about 2-fold in both models, Treatment of mice with anti-NGF prevented development of airway hyperresponsiveness (AHR). In the human study group, NGF levels in BALF after allergen provocation were correlated significantly with baseline FEV1 levels. Conclusion: These data strongly suggest that neurotrophins serve as a link between airway inflammation and neuronal control of ASM constriction in BA.