Exposure to organic solvents during pregnancy and oral clefts: A case-control study
Exposure to organic solvents during pregnancy and oral clefts: A case-control study
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DOI：
10.1016/0890-6238(95)02013-6
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发表时间：
1996-01-01
影响因子：
3.3
通讯作者：
Robert, E
中科院分区：
文献类型：
--
作者：
Laumon, B;Martin, JL;Robert, E
先前关于母亲接触有机溶剂与唇裂之间关系的研究并不一致。我们在 1985 年至 1989 年期间在法国罗纳-阿尔卑斯地区进行的一项病例对照研究中重新审视了这种关系。对于每个病例，我们选择了两个在同一个月出生的同一分娩单位中没有先天性异常的对照。我们在分娩后的前五天内采访了每位母亲，了解其之前的生育史和受孕后前两个月的暴露情况。如果母亲当时有职业活动，我们会要求她的职业医生确认接触情况。我们比较了 200 名唇裂和/或腭裂婴儿与 400 名对照婴儿的母亲接触任何有机溶剂的情况，估计比值比为 1.62（95% CI 1.04-2.52）。然后我们比较了九个溶剂亚组的暴露情况。只有与卤代脂肪族溶剂相关的优势比（4.40，95% CI 1.41-16.15）与统一有显着差异。控制潜在的混杂因素——孩子的性别、家族史、母亲癫痫——并没有改变这一比值比的估计。
Prior studies on the relationship between maternal exposure to organic solvents in relation to oral clefts have been inconsistent. We re-examined this relationship in a case-control study conducted in the Rhone-Alpes region of France during the years 1985 to 1989. For each case, we selected two controls without congenital anomalies in the same delivery unit born during the same month. We interviewed each mother within the first five days after delivery about previous reproductive history and exposures during the first two months after conception. If the mother had an occupational activity at that time, we asked her occupational physician to confirm the exposures. We compared maternal exposure to any organic solvent between 200 infants with cleft lip and/or cleft palate and 400 controls and the estimated odds ratio was 1.62 (95% CI 1.04-2.52). Then we compared exposures to nine subgroups of solvents. Only the odds ratio associated with halogenated aliphatic solvents (4.40, 95% CI 1.41-16.15) was significantly different from unity. Control of potential confounders-sex of child, family history, maternal epilepsy-did not alter this odds ratio estimate.