Common or redundant neural circuits for duration processing across audition and touch.
Common or redundant neural circuits for duration processing across audition and touch.
复制标题
DOI：
10.1523/jneurosci.3296-10.2011
复制
发表时间：
2011-03-02
期刊：
影响因子：
--
通讯作者：
Foxe JJ
中科院分区：
文献类型：
--
作者：
Butler JS;Molholm S;Fiebelkorn IC;Mercier MR;Schwartz TH;Foxe JJ
物体或事件的某些特征可以由一个以上的感觉系统来表示，例如表面的粗糙度（视觉，声音和触觉），说话者的位置（听觉和视觉）或事件的节奏或持续时间（所有三个主要感觉系统）。因此，这些性质可以说是与感觉无关的或无模式的。一个关键的问题是，共同的多感觉皮层区域是否处理这些非模态特征，或者每个感觉系统是否包含自己的专门区域来处理共同特征？我们通过研究听觉和触觉的简单持续时间检测机制来解决这个问题，特别是因为在这两个系统中都可以进行精细的持续时间区分。人类事件相关电位的失配负波（MMN）成分提供了一个敏感的度量的持续时间处理，它已被独立地在听觉和体感调查。采用高密度脑电图记录结合颅内硬膜下记录，我们问是否罚款持续时间歧视，代表的MMN，产生在相同的皮层区域，无论被探测的感觉方式。头皮记录指出，统计上不同的MMN地形跨感官，这意味着差异的底层皮层发电机配置。颅内记录证实了这些非侵入性的发现，显示发电机的听觉MMN沿着的上级颞回没有证据表明，在这个地区的体感MMN，而一个强大的体感MMN记录从中央后回的听觉MMN的情况下。目前的数据清楚地反对一个共同的电路解释非模态持续时间处理。
Certain features of objects or events can be represented by more than a single sensory system such as roughness of a surface (sight, sound and touch), the location of a speaker (audition and sight) or the rhythm or duration of an event (by all three major sensory systems). Thus, these properties can be said to be sensory-independent or amodal. A key question is whether common multisensory cortical regions process these amodal features, or does each sensory-system contain its own specialized region(s) for processing common features? We tackled this issue by investigating simple duration detection mechanisms across audition and touch, specifically because fine duration discriminations are possible in both systems. The mismatch negativity (MMN) component of the human event-related potential provides a sensitive metric of duration-processing and it has been elicited independently during both auditory and somatosensory investigations. Employing high-density electroencephalographic recordings in conjunction with intracranial subdural recordings, we asked whether fine duration discriminations, represented by the MMN, were generated in the same cortical regions regardless of the sensory modality being probed. Scalp-recordings pointed to statistically distinct MMN topographies across senses, implying differential underlying cortical generator configurations. Intracranial recordings confirmed these non-invasive findings, showing generators of the auditory MMN along the superior temporal gyrus with no evidence of a somatosensory MMN in this region, whereas a robust somatosensory MMN was recorded from post-central gyrus in the absence of an auditory MMN. The current data clearly argue against a common circuitry account for amodal duration processing.