Lewis Acid Enables Ketone Phosphorylation: Synthesis of Alkenyl Phosphonates
Lewis Acid Enables Ketone Phosphorylation: Synthesis of Alkenyl Phosphonates
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路易斯酸使酮磷酸化：烯基膦酸酯的合成
DOI：
10.1002/cjoc.202100083
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Qiong Su
中科院分区：
文献类型：
--
作者：
Xiao-Hong Wei;Chun-Yuan Bai;Lian-Biao Zhao;Ping Zhang;Zhen-Hua Li;Yan-Bin Wang;Qiong Su
主要观察和结论：发展了一种有效的刘易斯酸使酮膦酰化合成乙烯基膦酸酯的方法。该方法依赖于酮氢膦酸化/α-羟基膦酸酯单分子消除（E1）脱水级联反应序列。以中等至优异的产率获得了各种C-P键形成产物，其中水是反应中唯一的副产物。
Main observation and conclusion: An efficient Lewis acid enabled ketones phosphonylation to synthesize vinylphosphonates has been developed. This method relays on ketone hydrophosphonylation/α‐hydroxy phosphonates unimolecular elimination (E1) dehydration cascade reaction sequence. Various C—P bond formation products were obtained in moderate to excellent yields with water as the only byproduct in the reaction.