Tracking of appendicular bone mineral density for 6 years including the pubertal growth spurt: Japanese Population-based Osteoporosis Kids Cohort Study
Tracking of appendicular bone mineral density for 6 years including the pubertal growth spurt: Japanese Population-based Osteoporosis Kids Cohort Study
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DOI：
10.1007/s00774-010-0213-0
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发表时间：
2011-03-01
影响因子：
3.3
通讯作者：
Yoneshima, Hideo
中科院分区：
文献类型：
--
作者：
Fujita, Yuki;Iki, Masayuki;Yoneshima, Hideo
成年早期的骨骼发育在决定以后患骨质疏松症的风险方面起着重要作用。然而，日本儿童的纵向研究尚未充分记录儿童的骨发育。本研究的目的是确定从青春期前到6年随访的面骨密度（aBMD）的跟踪程度，并确定达到最大峰值aBMD的目标时期。本研究作为一项更大队列研究（日本人群骨质疏松症（JPOS）研究）的儿科部分进行。在完成基线调查的448名9-12岁儿童中，225名儿童在6年后参加了随访研究（随访率：50.2%）。采用双能X线骨密度仪测量前臂aBMD。青春期前儿童的基线aBMD值与6年随访时获得的aBMD值在两种性别中均显示出显著的追踪相关性（男孩r = 0.655，女孩r = 0.759）。虽然青春期前aBMD最低四分位数的男孩和女孩从青春期前到6年随访的aBMD年增长率高于其他四分位数的男孩和女孩，但他们在6年随访时的平均aBMD仍最低。在6年的随访中，青春期前aBMD较低的儿童的BMD增加更大，但增加的幅度不足以赶上其他儿童。在6年随访时，aBMD的变异中约有50%是由青春期前达到的aBMD决定的。增加aBMD的活动不仅对青春期的儿童很重要，对青春期前的儿童也很重要。
Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral density (aBMD) from pre-puberty to 6-year follow-up, and to determine the target period to achieve maximal peak aBMD. This study was conducted as the pediatric part of a larger cohort study, the Japanese Population-based Osteoporosis (JPOS) study. Of 448 children aged 9-12 years who completed the baseline survey, 225 participated in the follow-up study 6 years later (follow-up rate: 50.2%). aBMD at the forearm was measured using dual-energy X-ray absorptiometry. aBMD values in pre-pubertal children at baseline showed a significant tracking correlation with aBMD obtained at 6-year follow-up in both genders (boys r = 0.655, girls r = 0.759). Although boys and girls in the lowest quartile of aBMD pre-pubertally had greater annual increases in aBMD from pre-puberty to 6-year follow-up than those in other aBMD quartiles, they still showed the lowest mean aBMD at 6-year follow-up. Children with lower pre-pubertal aBMD showed greater increases in BMD up until 6-year follow-up, but the increase was not great enough to catch up with other children. About 50% of the variance in aBMD at 6-year follow-up was determined by the aBMD achieved during the pre-pubertal period. Activities that increase aBMD are important not only for children during puberty, but also for younger pre-pubertal children.