Gene Expression and Methylation Analyses Suggest DCTD as a Prognostic Factor in Malignant Glioma.
Gene Expression and Methylation Analyses Suggest DCTD as a Prognostic Factor in Malignant Glioma.
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DOI：
10.1038/s41598-017-11962-y
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发表时间：
2017-09-14
影响因子：
4.6
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Hu H;Wang Z;Li M;Zeng F;Wang K;Huang R;Wang H;Yang F;Liang T;Huang H;Jiang T
恶性神经胶质瘤是最常见的脑癌，预后很差。患者生存时间的个体差异显著。在这里，我们研究了恶性胶质瘤患者的转录组和启动子甲基化差异，（不到一年）和长期患者CGGA中的生存期（3年以上）（中国胶质瘤基因组图谱），并验证了TCGA的差异（The Cancer Genome Atlas）来鉴定其表达水平与胶质瘤患者的预后高度一致的基因，并在恶性进展中发挥重要作用。在不同的数据库中，发现编码遗传物质合成中的关键酶dCMP脱氨酶（DCTD）的基因与总生存率显著相关，并且高水平的DCTD mRNA表明恶性胶质瘤患者的生存期较短。我们的发现显示DCTD是恶性胶质瘤的一个有效的预后因子。由于DCTD抑制剂吉西他滨已被提议作为恶性胶质瘤的辅助治疗，我们的发现也表明吉西他滨对DCTD高表达水平的患者具有治疗价值。
Malignant glioma is the most common brain cancer with dismal outcomes. Individual variation of the patients’ survival times is remarkable. Here, we investigated the transcriptome and promoter methylation differences between patients of malignant glioma with short (less than one year) and the patients with long (more than three years) survival in CGGA (Chinese Glioma Genome Atlas), and validated the differences in TCGA (The Cancer Genome Atlas) to identify the genes whose expression levels showed high concordance with prognosis of glioma patients, as well as played an important role in malignant progression. The gene coding a key enzyme in genetic material synthesis, dCMP deaminase (DCTD), was found to be significantly correlated with overall survival and high level of DCTD mRNA indicated shorter survival of the patients with malignant glioma in different databases. Our finding revealed DCTD as an efficient prognostic factor for malignant glioma. As DCTD inhibitor gemcitabine has been proposed as an adjuvant therapy for malignant glioma, our finding also suggests a therapeutic value of gemcitabine for the patients with high expression level of DCTD.
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影响因子：
158.5
作者：
WALKER, MD;GREEN, SB;STRIKE, TA
通讯作者：
STRIKE, TA
CGCG 成人弥漫性胶质瘤治疗临床实践指南。
影响因子：
9.7
作者：
Jiang, Tao;Mao, Ying;Wang, Qixue
通讯作者：
Wang, Qixue
影响因子：
--
作者：
Yang P;Zhang C;Cai J;You G;Wang Y;Qiu X;Li S;Wu C;Yao K;Li W;Peng X;Zhang W;Jiang T
通讯作者：
Jiang T
影响因子：
64.5
作者：
Brennan CW;Verhaak RG;McKenna A;Campos B;Noushmehr H;Salama SR;Zheng S;Chakravarty D;Sanborn JZ;Berman SH;Beroukhim R;Bernard B;Wu CJ;Genovese G;Shmulevich I;Barnholtz-Sloan J;Zou L;Vegesna R;Shukla SA;Ciriello G;Yung WK;Zhang W;Sougnez C;Mikkelsen T;Aldape K;Bigner DD;Van Meir EG;Prados M;Sloan A;Black KL;Eschbacher J;Finocchiaro G;Friedman W;Andrews DW;Guha A;Iacocca M;O'Neill BP;Foltz G;Myers J;Weisenberger DJ;Penny R;Kucherlapati R;Perou CM;Hayes DN;Gibbs R;Marra M;Mills GB;Lander E;Spellman P;Wilson R;Sander C;Weinstein J;Meyerson M;Gabriel S;Laird PW;Haussler D;Getz G;Chin L;TCGA Research Network
通讯作者：
TCGA Research Network
基因表达的多维分析表明 TGFB1I1 诱导的 EMT 有助于星形细胞瘤的恶性进展。
影响因子：
--
作者：
Liu Y;Hu H;Wang K;Zhang C;Wang Y;Yao K;Yang P;Han L;Kang C;Zhang W;Jiang T
通讯作者：
Jiang T