A comparison of neurocognition and functioning in first episode psychosis populations: do research samples reflect the real world?
A comparison of neurocognition and functioning in first episode psychosis populations: do research samples reflect the real world?
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DOI：
10.1007/s00127-018-1631-x
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发表时间：
2019-03-01
影响因子：
4.4
通讯作者：
Seidman, Larry J.
中科院分区：
文献类型：
--
作者：
Kline, Emily;Hendel, Victoria;Seidman, Larry J.
目的：本研究评估了在同一中心和同一时间段内接受评估和治疗的FEP研究样本、研究对照组和FEP临床样本的人口学、临床和神经认知特征。方法本研究通过观察性研究和回顾性图表分析收集数据。在青少年和成人临床状态和脑功能的纵向评估与监测研究和早期精神病的预防与康复临床中确定样本。FEP临床患者（n=77）， FEP研究参与者（n=44）和年龄匹配的对照组（n=38）使用matrix共识认知电池和全球功能社会和角色量表进行评估。通过单因素方差分析和卡方分析评估组间差异。结果两组间年龄、性别差异无统计学意义。与FEP临床人群相比，FEP研究样本中白人参与者的比例更高，社会和角色功能更好，神经认知表现也更好。与FEP研究样本相比，临床样本也有更多的诊断变异性和更高的物质使用障碍患病率。研究人员应该意识到研究设计和招募实践如何影响样本的代表性，特别关注少数种族和更严重疾病患者的平等代表性。研究的设计应尽量减少负担，以促进更广泛的参与。
PurposeThe current study evaluates the demographic, clinical, and neurocognitive characteristics of a recruited FEP research sample, a research control group, and a FEP clinic sample that were assessed and treated within the same center and time period.MethodsThis study utilized data collected through an observational study and a retrospective chart review. Samples were ascertained in the Longitudinal Assessment and Monitoring of Clinical Status and Brain Function in Adolescents and Adults study and the Prevention and Recovery in Early Psychosis clinic. FEP clinic patients (n=77), FEP research participants (n=44), and age-matched controls (n=38) were assessed using the MATRICS consensus cognitive battery and global functioning social and role scales. Between-group differences were assessed via one-way ANOVA and Chi-square analyses.ResultsNo significant differences were observed between groups with regard to age and gender. The FEP research sample had a higher proportion of white participants, better social and role functioning, and better neurocognitive performance when compared with the FEP clinical population. The clinic sample also had more diagnostic variability and higher prevalence of substance use disorders relative to the FEP research sample.ConclusionsResearchers should be aware of how study design and recruitment practices may impact the representativeness of samples, with particular concern for equal representation of racial minorities and patients with more severe illness. Studies should be designed to minimize burden to promote a wider range of participation.