The Lateral Habenula Circuitry: Reward Processing and Cognitive Control
The Lateral Habenula Circuitry: Reward Processing and Cognitive Control
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DOI：
10.1523/jneurosci.2350-16.2016
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发表时间：
2016-11-09
影响因子：
5.3
通讯作者：
Vicentic, Aleksandra
中科院分区：
文献类型：
--
作者：
Baker, Phillip M.;Jhou, Thomas;Vicentic, Aleksandra
近年来，人们对外侧缰核（LHb）在奖赏加工、情感调节和目标导向行为中的作用越来越感兴趣。LHb的主要输入来自缰核投射苍白球和mPFC，将其传出神经发送到多巴胺能VTA和SNc，多巴胺能中缝背核和GABA能嘴内侧被盖核。最近的研究在我们对LHb电路组织的理解方面取得了进展，但其参与复杂行为的确切机制在很大程度上是未知的。为了开始解决这个悬而未决的问题，我们在这里提出了新兴的跨物种的观点，目标是提供一个更精细的理解的作用，LHb电路的奖励和认知。我们开始强调最近的研究结果，从啮齿动物实验中使用光遗传学，电生理学，分子，药理学和跟踪技术，揭示不同的神经表型的LHb电路，可能是以前未描述的行为功能的基础。然后，我们讨论了猕猴的电生理研究结果表明，LHb与前扣带皮层合作，以监测行动的结果和信号的行为调整。最后，我们提供了一个跨物种的研究结果的综合总结，并讨论如何进一步研究的连接，神经信号，和生理学的LHb电路可以加深我们的理解LHb的正常和适应不良行为与精神疾病和药物滥用的作用。
There has been a growing interest in understanding the role of the lateral habenula (LHb) in reward processing, affect regulation, and goal-directed behaviors. The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc, serotonergic dorsal raphe nuclei, and the GABAergic rostromedial tegmental nucleus. Recent studies have made advances in our understanding of the LHb circuit organization, yet the precise mechanisms of its involvement in complex behaviors are largely unknown. To begin to address this unresolved question, we present here emerging cross-species perspectives with a goal to provide a more refined understanding of the role of the LHb circuits in reward and cognition. We begin by highlighting recent findings from rodent experiments using optogenetics, electrophysiology, molecular, pharmacology, and tracing techniques that reveal diverse neural phenotypes in the LHb circuits that may underlie previously undescribed behavioral functions. We then discuss results from electrophysiological studies in macaques that suggest that the LHb cooperates with the anterior cingulate cortex to monitor action outcomes and signal behavioral adjustment. Finally, weprovide an integrated summary of cross-species findings and discuss how further research on the connectivity, neural signaling, and physiology of the LHb circuits can deepen our understanding of the role of the LHb in normal and maladaptive behaviors associated with mental illnesses and drug abuse.